                         SEQUENCE LISTING

<110>  AviGenics, Inc.
 
<120>  Transgene Expression in Avians

<130>  AVI-065

<160>  29    

<170>  PatentIn version 3.4

<210>  1
<211>  9597
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  pALV-SIN-4.2-Lys-IFNa-2B Vector

<400>  1
gatcccccgt gctgcagaac cgagcggcta ttgacttctt gctcctagct cacggccatg     60

gctgtgagga cattgcggga atgtgttgtt tcaatctgag tgatcacagt gagtctatac    120

agaagaagtt ccagctaatg aaggaacatg tcaataagat cggcgtgaac aacgacccaa    180

tcggaagttg gctgcgagga ttattcggag gaataggaga atgggccgta cacttgctga    240

aaggactgct tttggggctt gtagttatct tgttgctagt agtatgcttg ccttgccttt    300

tgcaatgtgt atctagtagt attcgaaaga tgattgataa ttcactcggc tatcgcgagg    360

aatataaaaa aattacagga ggcttataag cagcccgaaa gaagagcgta ggcgagttct    420

tgtattccgt gtgatagctg gttggattgg taattgatcg gctggcacgc ggaatatagg    480

aggtcgctga atagtaaact tgtagacttg gctacagcat agagtatctt ctgtagctct    540

gatgactgct aggaaataat gctacggata atgtggggag ggcaaggctt gcgaatcggg    600

ttgtaacggg caaggcttga ctgaggggac aatagcatgt ttaggcgaaa agcggggctt    660

cggttgtacg cggttaggag tcccctcagg atatagtagt ttcgcttttg catagggagg    720

gggacggatt ggacgaacca ctgaattccg cattgcagag atattgtatt taagtgccta    780

gctcgataca ataaacgcca tttgaccatt caccacattg gtgtgcacct gggttgatgg    840

ccggaccgtt gattccctgr cgactacgag cacatgcatg aagcagaagg cttcatttgg    900

tgaccccgac gtgatcgtta gggaatacgc gctcactggc cgtcgtttta caacgtcgtg    960

actgggaaaa ccctggcgtt acccaactta atcgccttgc agcacatccc cctttcgcca   1020

gctggcgtaa tagcgaagag gcccgcaccg atcgcccttc ccaacagttg cgcagcctga   1080

atggcgaatg gaaattgtaa gcgttaatat tttgttaaaa ttcgcgttaa atttttgtta   1140

aatcagctca ttttttaacc aataggccga aatcggcaaa atcccttata aatcaaaaga   1200

atagaccgag atagggttga gtgttgttcc agtttggaac aagagtccac tattaaagaa   1260

cgtggactcc aacgtcaaag ggcgaaaaac cgtctatcag ggcgatggcc cactacgtga   1320

accatcaccc taatcaagtt ttttggggtc gaggtgccgt aaagcactaa atcggaaccc   1380

taaagggagc ccccgattta gagcttgacg gggaaagccg gcgaacgtgg cgagaaagga   1440

agggaagaaa gcgaaaggag cgggcgctag ggcgctggca agtgtagcgg tcacgctgcg   1500

cgtaaccacc acacccgccg cgcttaatgc gccgctacag ggcgcgtcag gtggcacttt   1560

tcggggaaat gtgcgcggaa cccctatttg tttatttttc taaatacatt caaatatgta   1620

tccgctcatg agacaataac cctgataaat gcttcaataa tattgaaaaa ggaagagtat   1680

gagtattcaa catttccgtg tcgcccttat tccctttttt gcggcatttt gccttcctgt   1740

ttttgctcac ccagaaacgc tggtgaaagt aaaagatgct gaagatcagt tgggtgcacg   1800

agtgggttac atcgaactgg atctcaacag cggtaagatc cttgagagtt ttcgccccga   1860

agaacgtttt ccaatgatga gcacttttaa agttctgcta tgtggcgcgg tattatcccg   1920

tattgacgcc gggcaagagc aactcggtcg ccgcatacac tattctcaga atgacttggt   1980

tgagtactca ccagtcacag aaaagcatct tacggatggc atgacagtaa gagaattatg   2040

cagtgctgcc ataaccatga gtgataacac tgcggccaac ttacttctga caacgatcgg   2100

aggaccgaag gagctaaccg cttttttgca caacatgggg gatcatgtaa ctcgccttga   2160

tcgttgggaa ccggagctga atgaagccat accaaacgac gagcgtgaca ccacgatgcc   2220

tgtagcaatg gcaacaacgt tgcgcaaact attaactggc gaactactta ctctagcttc   2280

ccggcaacaa ttaatagact ggatggaggc ggataaagtt gcaggaccac ttctgcgctc   2340

ggcccttccg gctggctggt ttattgctga taaatctgga gccggtgagc gtgggtctcg   2400

cggtatcatt gcagcactgg ggccagatgg taagccctcc cgtatcgtag ttatctacac   2460

gacggggagt caggcaacta tggatgaacg aaatagacag atcgctgaga taggtgcctc   2520

actgattaag cattggtaac tgtcagacca agtttactca tatatacttt agattgattt   2580

aaaacttcat ttttaattta aaaggatcta ggtgaagatc ctttttgata atctcatgac   2640

caaaatccct taacgtgagt tttcgttcca ctgagcgtca gaccccgtag aaaagatcaa   2700

aggatcttct tgagatcctt tttttctgcg cgtaatctgc tgcttgcaaa caaaaaaacc   2760

accgctacca gcggtggttt gtttgccgga tcaagagcta ccaactcttt ttccgaaggt   2820

aactggcttc agcagagcgc agataccaaa tactgtcctt ctagtgtagc cgtagttagg   2880

ccaccacttc aagaactctg tagcaccgcc tacatacctc gctctgctaa tcctgttacc   2940

agtggctgct gccagtggcg ataagtcgtg tcttaccggg ttggactcaa gacgatagtt   3000

accggataag gcgcagcggt cgggctgaac ggggggttcg tgcacacagc ccagcttgga   3060

gcgaacgacc tacaccgaac tgagatacct acagcgtgag ctatgagaaa gcgccacgct   3120

tcccgaaggg agaaaggcgg acaggtatcc ggtaagcggc agggtcggaa caggagagcg   3180

cacgagggag cttccagggg gaaacgcctg gtatctttat agtcctgtcg ggtttcgcca   3240

cctctgactt gagcgtcgat ttttgtgatg ctcgtcaggg gggcggagcc tatggaaaaa   3300

cgccagcaac gcggcctttt tacggttcct ggccttttgc tggccttttg ctcacatgtt   3360

ctttcctgcg ttatcccctg attctgtgga taaccgtatt accgcctttg agtgagctga   3420

taccgctcgc cgcagccgaa cgaccgagcg cagcgagtca gtgagcgagg aagcggaaga   3480

gcgcccaata cgcaaaccgc ctctccccgc gcgttggccg attcattaat gcagctggca   3540

cgacaggttt cccgactgga aagcgggcag tgagcgcaac gcaattaatg tgagttagct   3600

cactcattag gcaccccagg ctttacactt tatgcttccg gctcgtatgt tgtgtggaat   3660

tgtgagcgga taacaatttc acacaggaaa cagctatgac catgattacg ccaagcgcgc   3720

attggtaatt gatcggctgg cacgcggaat ataggaggtc gctgaatagt aaacttgtag   3780

acttggctac agcatagagt atcttctgta gctctgatga ctgctaggaa ataatgctac   3840

ggataatgtg gggagggcaa ggcttgcgaa tcgggttgta acgggcaagg cttgactgag   3900

gggacaatag catgtttagg cgaaaagcgg ggcttcggtt gtacgcggtt aggagtcccc   3960

tcaggatata gtagtttcgc ttttgcatag ggagggggaa atgtagtctt atgcaatact   4020

cttgtagtct tgcaacatgc ttatgtaacg atgagttagc aacatgcctt ataaggagag   4080

aaaaagcacc gtgcatgccg attggtggga gtaaggtggt atgatcgtgg tatgatcgtg   4140

ccttgttagg aaggcaacag acgggtctaa cacggattgg acgaaccact gaattccgca   4200

ttgcagagat attgtattta agtgcctagc tcgatacaat aaacgccatt tgaccattca   4260

ccacattggt gtgcacctgg gttgatggcc ggaccgttga ttccctgrcg actacgagca   4320

catgcatgaa gcagaaggct tcatttggtg accccgacgt gatcgttagg gaatagtggt   4380

cggccacagg cggcgtggcg atcctgtcct catccgtctc gcttattcgg ggagcggacg   4440

atgaccctag tagagggggc tgcggcttag gagggcagaa gctgagtggc gtcggaggga   4500

gccctactgc agggggccaa cataccctac cgagaactca gagagtcgtt ggaagacggg   4560

aaggaagccc gacgactgag cggtccaccc caggcgtgat tccggttgct ctgcgtgatt   4620

ccggtcgccc ggtggatcaa gcatggaagc cgtcataaag gtgatttcgt ccgcgtgtaa   4680

gacctattgc gggaaaacct ctccttctaa gaaggaaata ggggctatgt tgtccctgtt   4740

acaaaaggaa gggttgctta cgtccccctc agacttatat tccccggggt cctgggatcc   4800

gataccgtcc ctatttttgt gtttgcttca gcagccattt aattcttcag tgtcatcttg   4860

ttctgttgat gccactggaa caggattttc agcagtcttg caaagaacat ctagctgaaa   4920

actttctgcc attcaatatt cttaccagtt cttcttgttt gaggtgagcc ataaattact   4980

agaacttcgt cactgacaag tttatgcatt ttattacttc tattatgtac ttactttgac   5040

ataacacaga cacgcacata ttttgctggg atttccacag tgtctctgtg tccttcacat   5100

ggttttactg tcatacttcc gttataacct tggcaatctg cccagctgcc catcacaaga   5160

aaagagattc cttttttatt acttctcttc agccaataaa caaaatgtga gaagcccaaa   5220

caagaacttg tggggcaggc tgccatcaag ggagagacag ctgaagggtt gtgtagctca   5280

atagaattaa gaaataataa agctgtgtca gacagttttg cctgatttat acaggcacgc   5340

cccaagccag agaggctgtc tgccaaggcc accttgcagt ccttggtttg taagataagt   5400

cataggtaac ttttctggtg aattgcgtgg agaatcatga tggcagttct tgctgtttac   5460

tatggtaaga tgctaaaata ggagacagca aagtaacact tgctgctgta ggtgctctgc   5520

tatccagaca gcgatggcac tcgcacacca agatgaggga tgctcccagc tgacggatgc   5580

tggggcagta acagtgggtc ccatgctgcc tgctcattag catcacctca gccctcacca   5640

gcccatcaga aggatcatcc caagctgagg aaagttgctc atcttcttca catcatcaaa   5700

cctttggcct gactgatgcc tcccggatgc ttaaatgtgg tcactgacat ctttattttt   5760

ctatgatttc aagtcagaac ctccggatca ggagggaaca catagtggga atgtaccctc   5820

agctccaagg ccagatcttc cttcaatgat catgcatgct acttaggaag gtgtgtgtgt   5880

gtgaatgtag aattgccttt gttatttttt cttcctgctg tcaggaacat tttgaatacc   5940

agagaaaaag aaaagtgctc ttcttggcat gggaggagtt gtcacacttg caaaataaag   6000

gatgcagtcc caaatgttca taatctcagg gtctgaagga ggatcagaaa ctgtgtatac   6060

aatttcaggc ttctctgaat gcagcttttg aaagctgttc ctggccgagg cagtactagt   6120

cagaaccctc ggaaacagga acaaatgtct tcaaggtgca gcaggaggaa acaccttgcc   6180

catcatgaaa gtgaataacc actgccgctg aaggaatcca gctcctgttt gagcaggtgc   6240

tgcacactcc cacactgaaa caacagttca tttttatagg acttccagga aggatcttct   6300

tcttaagctt cttaattatg gtacatctcc agttggcaga tgactatgac tactgacagg   6360

agaatgagga actagctggg aatatttctg tttgaccacc atggagtcac ccatttcttt   6420

actggtattt ggaaataata attctgaatt gcaaagcagg agttagcgaa gatcttcatt   6480

tcttccatgt tggtgacagc acagttctgg ctatgaaagt ctgcttacaa ggaagaggat   6540

aaaaatcata gggataataa atctaagttt gaagacaatg aggttttagc tgcatttgac   6600

atgaagaaat tgagacctct actggatagc tatggtattt acgtgtcttt ttgcttagtt   6660

acttattgac cccagctgag gtcaagtatg aactcaggtc tctcgggcta ctggcatgga   6720

ttgattacat acaactgtaa ttttagcagt gatttagggt ttatgagtac ttttgcagta   6780

aatcataggg ttagtaatgt taatctcagg gaaaaaaaaa aaaagccaac cctgacagac   6840

atcccagctc aggtggaaat caaggatcac agctcagtgc ggtcccagag aacacaggga   6900

ctcttctctt aggaccttta tgtacagggc ctcaagataa ctgatgttag tcagaagact   6960

ttccattctg gccacagttc agctgaggca atcctggaat tttctctccg ctgcacagtt   7020

ccagtcatcc cagtttgtac agttctggca ctttttgggt caggccgtga tccaaggagc   7080

agaagttcca gctatggtca gggagtgcct gaccgtccca actcactgca ctcaaacaaa   7140

ggcgaaacca caagagtggc ttttgttgaa attgcagtgt ggcccagagg ggctgcacca   7200

gtactggatt gaccacgagg caacattaat cctcagcaag tgcaatttgc agccattaaa   7260

ttgaactaac tgatactaca atgcaatcag tatcaacaag tggtttggct tggaagatgg   7320

agtctagggg ctctacagga gtagctactc tctaatggag ttgcattttg aagcaggaca   7380

ctgtgaaaag ctggcctcct aaagaggctg ctaaacatta gggtcaattt tccagtgcac   7440

tttctgaagt gtctgcagtt ccccatgcaa agctgcccaa acatagcact tccaattgaa   7500

tacaattata tgcaggcgta ctgcttcttg ccagcactgt ccttctcaaa tgaactcaac   7560

aaacaatttc aaagtctagt agaaagtaac aagctttgaa tgtcattaaa aagtatatct   7620

gctttcagta gttcagctta tttatgccca ctagaaacat cttgtacaag ctgaacactg   7680

gggctccaga ttagtggtaa aacctacttt atacaatcat agaatcatag aatggcctgg   7740

gttggaaggg accccaagga tcatgaagat ccaacacccc cgccacaggc agggccacca   7800

acctccagat ctggtactag accaggcagc ccagggctcc atccaacctg gccatgaaca   7860

cctccaggga tggagcatcc acaacctctc tgggcagcct gtgccagcac ctcaccaccc   7920

tctctgtgaa gaacttttcc ctgacatcca atctaagcct tccctccttg aggttagatc   7980

cactccccct tgtgctatca ctgtctactc ttgtaaaaag ttgattctcc tcctttttgg   8040

aaggttgcaa tgaggtctcc ttgcagcctt cttctcttct gcaggatgaa caagcccagc   8100

tccctcagcc tgtctttata ggagaggtgc tccagccctc tgatcatctt tgtggccctc   8160

ctctggaccc gctccaagag ctccacatct ttcctgtact gggggcccca ggcctgaatg   8220

cagtactcca gatggggcct caaaagagca gagtaaagag ggacaatcac cttcctcacc   8280

ctgctggcca gccctcttct gatggagccc tggatacaac tggctttctg agctgcaact   8340

tctccttatc agttccacta ttaaaacagg aacaatacaa caggtgctga tggccagtgc   8400

agagtttttc acacttcttc atttcggtag atcttagatg aggaacgttg aagttgtgct   8460

tctgcgtgtg cttcttcctc ctcaaatact cctgcctgat acctcacccc acctgccact   8520

gaatggctcc atggccccct gcagccaggg ccctgatgaa cccggcactg cttcagatgc   8580

tgtttaatag cacagtatga ccaagttgca cctatgaata cacaaacaat gtgttgcatc   8640

cttcagcact tgagaagaag agccaaattt gcattgtcag gaaatggttt agtaattctg   8700

ccaattaaaa cttgtttatc taccatggct gtttttatgg ctgttagtag tggtacactg   8760

atgatgaaca atggctatgc agtaaaatca agactgtaga tattgcaaca gactataaaa   8820

ttcctctgtg gcttagccaa tgtggtactt cccacattgt ataagaaatt tggcaagttt   8880

agagcaatgt ttgaagtgtt gggaaatttc tgtatactca agagggcgtt tttgacaact   8940

gtagaacaga ggaatcaaaa gggggtggga ggaagttaaa agaagaggca ggtgcaagag   9000

agcttgcagt cccgctgtgt gtacgacact ggcaacatga ggtctttgct aatcttggtg   9060

ctttgcttcc tgcccctggc tgccttaggg tgcgatctgc ctcagaccca cagcctgggc   9120

agcaggagga ccctgatgct gctggctcag atgaggagaa tcagcctgtt tagctgcctg   9180

aaggataggc acgattttgg ctttcctcaa gaggagtttg gcaaccagtt tcagaaggct   9240

gagaccatcc ctgtgctgca cgagatgatc cagcagatct ttaacctgtt tagcaccaag   9300

gatagcagcg ctgcttggga tgagaccctg ctggataagt tttacaccga gctgtaccag   9360

cagctgaacg atctggaggc ttgcgtgatc cagggcgtgg gcgtgaccga gacccctctg   9420

atgaaggagg atagcatcct ggctgtgagg aagtactttc agaggatcac cctgtacctg   9480

aaggagaaga agtacagccc ctgcgcttgg gaagtcgtga gggctgagat catgaggagc   9540

tttagcctga gcaccaacct gcaagagagc ttgaggtcta aggagtaaaa agtctag      9597


<210>  2
<211>  28
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer ALV-SIN-1

<400>  2
atgcgcgcat tggtaattga tcggctgg                                        28


<210>  3
<211>  80
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer ALV-SIN-2

<400>  3
atatgcggcc gcggtaccgc ccgggcatcg atatcaagct tacggttcac taaacgagct     60

ctgcttatat agacctccca                                                 80


<210>  4
<211>  59
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer ALV-SIN-3

<400>  4
atatgcggcc gcgtcgacgg ccggccagat ctgctgagcc ggtcgctacc attaccagt      59


<210>  5
<211>  28
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer ALV-SIN-4

<400>  5
atacgcgtat tccctaacga tcacgtcg                                        28


<210>  6
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer ALV-SIN-5

<400>  6
ctgaagtgta aggaatgtaa g                                               21


<210>  7
<211>  30
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer ALV-SIN-6

<400>  7
gcgcgtctca tccccctccc tatgcaaaag                                      30


<210>  8
<211>  37
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer ALV-SIN-7

<400>  8
gggcgtctca gggacggatt ggacgaacca ctgaatt                              37


<210>  9
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer ALV-SIN-8

<400>  9
ttagtgcttt acggcacctc                                                 20


<210>  10
<211>  38
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer ALV-SIN-9

<400>  10
gacggatccg ataccgtccc tatttttgtg tttgcttc                             38


<210>  11
<211>  30
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer ALV-SIN-10

<400>  11
taacggatcc tagacttttt actccttaga                                      30


<210>  12
<211>  11945
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Proximal promoter and lysozyme signal peptide

<400>  12
tgccgccttc tttgatattc actctgttgt atttcatctc ttcttgccga tgaaaggata     60

taacagtctg tataacagtc tgtgaggaaa tacttggtat ttcttctgat cagtgttttt    120

ataagtaatg ttgaatattg gataaggctg tgtgtccttt gtcttgggag acaaagccca    180

cagcaggtgg tggttggggt ggtggcagct cagtgacagg agaggttttt ttgcctgttt    240

tttttttttt tttttttttt aagtaaggtg ttcttttttc ttagtaaatt ttctactgga    300

ctgtatgttt tgacaggtca gaaacatttc ttcaaaagaa gaaccttttg gaaactgtac    360

agcccttttc tttcattccc tttttgcttt ctgtgccaat gcctttggtt ctgattgcat    420

tatggaaaac gttgatcgga acttgaggtt tttatttata gtgtggcttg aaagcttgga    480

tagctgttgt tacacgagat accttattaa gtttaggcca gcttgatgct ttattttttc    540

cctttgaagt agtgagcgtt ctctggtttt tttcctttga aactggtgag gcttagattt    600

ttctaatggg attttttacc tgatgatcta gttgcatacc caaatgcttg taaatgtttt    660

cctagttaac atgttgataa cttcggattt acatgttgta tatacttgtc atctgtgttt    720

ctagtaaaaa tatatggcat ttatagaaat acgtaattcc tgatttcctt tttttttatc    780

tctatgctct gtgtgtacag gtcaaacaga cttcactcct atttttattt atagaatttt    840

atatgcagtc tgtcgttggt tcttgtgttg taaggataca gccttaaatt tcctagagcg    900

atgctcagta aggcgggttg tcacatgggt tcaaatgtaa aacgggcacg tttggctgct    960

gccttcccga gatccaggac actaaactgc ttctgcactg aggtataaat cgcttcagat   1020

cccagggaag tgcagatcca cgtgcatatt cttaaagaag aatgaatact ttctaaaata   1080

ttttggcata ggaagcaagc tgcatggatt tgtttgggac ttaaattatt ttggtaacgg   1140

agtgcatagg ttttaaacac agttgcagca tgctaacgag tcacagcgtt tatgcagaag   1200

tgatgcctgg atgcctgttg cagctgttta cggcactgcc ttgcagtgag cattgcagat   1260

aggggtgggg tgctttgtgt cgtgttccca cacgctgcca cacagccacc tcccggaaca   1320

catctcacct gctgggtact tttcaaacca tcttagcagt agtagatgag ttactatgaa   1380

acagagaagt tcctcagttg gatattctca tgggatgtct tttttcccat gttgggcaaa   1440

gtatgataaa gcatctctat ttgtaaatta tgcacttgtt agttcctgaa tcctttctat   1500

agcaccactt attgcagcag gtgtaggctc tggtgtggcc tgtgtctgtg cttcaatctt   1560

ttaaagcttc tttggaaata cactgacttg attgaagtct cttgaagata gtaaacagta   1620

cttacctttg atcccaatga aatcgagcat ttcagttgta aaagaattcc gcctattcat   1680

accatgtaat gtaattttac acccccagtg ctgacacttt ggaatatatt caagtaatag   1740

actttggcct caccctcttg tgtactgtat tttgtaatag aaaatatttt aaactgtgca   1800

tatgattatt acattatgaa agagacattc tgctgatctt caaatgtaag aaaatgagga   1860

gtgcgtgtgc ttttataaat acaagtgatt gcaaattagt gcaggtgtcc ttaaaaaaaa   1920

aaaaaaaaag taatataaaa aggaccaggt gttttacaag tgaaatacat tcctatttgg   1980

taaacagtta catttttatg aagattacca gcgctgctga ctttctaaac ataaggctgt   2040

attgtcttcc tgtaccattg catttcctca ttcccaattt gcacaaggat gtctgggtaa   2100

actattcaag aaatggcttt gaaatacagc atgggagctt gtctgagttg gaatgcagag   2160

ttgcactgca aaatgtcagg aaatggatgt ctctcagaat gcccaactcc aaaggatttt   2220

atatgtgtat atagtaagca gtttcctgat tccagcaggc caaagagtct gctgaatgtt   2280

gtgttgccgg agacctgtat ttctcaacaa ggtaagatgg tatcctagca actgcggatt   2340

ttaatacatt ttcagcagaa gtacttagtt aatctctacc tttagggatc gtttcatcat   2400

ttttagatgt tatacttgaa atactgcata acttttagct ttcatgggtt cctttttttc   2460

agcctttagg agactgttaa gcaatttgct gtccaacttt tgtgttggtc ttaaactgca   2520

atagtagttt accttgtatt gaagaaataa agaccatttt tatattaaaa aatacttttg   2580

tctgtcttca ttttgacttg tctgatatcc ttgcagtgcc cattatgtca gttctgtcag   2640

atattcagac atcaaaactt aacgtgagct cagtggagtt acagctgcgg ttttgatgct   2700

gttattattt ctgaaactag aaatgatgtt gtcttcatct gctcatcaaa cacttcatgc   2760

agagtgtaag gctagtgaga aatgcataca tttattgata cttttttaaa gtcaactttt   2820

tatcagattt ttttttcatt tggaaatata ttgttttcta gactgcatag cttctgaatc   2880

tgaaatgcag tctgattggc atgaagaagc acagcactct tcatcttact taaacttcat   2940

tttggaatga aggaagttaa gcaagggcac aggtccatga aatagagaca gtgcgctcag   3000

gagaaagtga acctggattt ctttggctag tgttctaaat ctgtagtgag gaaagtaaca   3060

cccgattcct tgaaagggct ccagctttaa tgcttccaaa ttgaaggtgg caggcaactt   3120

ggccactggt tatttactgc attatgtctc agtttcgcag ctaacctggc ttctccacta   3180

ttgagcatgg actatagcct ggcttcagag gccaggtgaa ggttgggatg ggtggaagga   3240

gtgctgggct gtggctgggg ggactgtggg gactccaagc tgagcttggg gtgggcagca   3300

cagggaaaag tgtgggtaac tatttttaag tactgtgttg caaacgtctc atctgcaaat   3360

acgtagggtg tgtactctcg aagattaaca gtgtgggttc agtaatatat ggatgaattc   3420

acagtggaag cattcaaggg tagatcatct aacgacacca gatcatcaag ctatgattgg   3480

aagcggtatc agaagagcga ggaaggtaag cagtcttcat atgttttccc tccacgtaaa   3540

gcagtctggg aaagtagcac cccttgagca gagacaagga aataattcag gagcatgtgc   3600

taggagaact ttcttgctga attctacttg caagagcttt gatgcctggc ttctggtgcc   3660

ttctgcagca cctgcaaggc ccagagcctg tggtgagctg gagggaaaga ttctgctcaa   3720

gtccaagctt cagcaggtca ttgtctttgc ttcttccccc agcactgtgc agcagagtgg   3780

aactgatgtc gaagcctcct gtccactacc tgttgctgca ggcagactgc tctcagaaaa   3840

agagagctaa ctctatgcca tagtctgaag gtaaaatggg ttttaaaaaa gaaaacacaa   3900

aggcaaaacc ggctgcccca tgagaagaaa gcagtggtaa acatggtaga aaaggtgcag   3960

aagcccccag gcagtgtgac aggcccctcc tgccacctag aggcgggaac aagcttccct   4020

gcctagggct ctgcccgcga agtgcgtgtt tctttggtgg gttttgtttg gcgtttggtt   4080

ttgagattta gacacaaggg aagcctgaaa ggaggtgttg ggcactattt tggtttgtaa   4140

agcctgtact tcaaatatat attttgtgag ggagtgtagc gaattggcca atttaaaata   4200

aagttgcaag agattgaagg ctgagtagtt gagagggtaa cacgtttaat gagatcttct   4260

gaaactactg cttctaaaca cttgtttgag tggtgagacc ttggataggt gagtgctctt   4320

gttacatgtc tgatgcactt gcttgtcctt ttccatccac atccatgcat tccacatcca   4380

cgcatttgtc acttatccca tatctgtcat atctgacata cctgtctctt cgtcacttgg   4440

tcagaagaaa cagatgtgat aatccccagc cgccccaagt ttgagaagat ggcagttgct   4500

tctttccctt tttcctgcta agtaaggatt ttctcctggc tttgacacct cacgaaatag   4560

tcttcctgcc ttacattctg ggcattattt caaatatctt tggagtgcgc tgctctcaag   4620

tttgtgtctt cctactctta gagtgaatgc tcttagagtg aaagagaagg aagagaagat   4680

gttggccgca gttctctgat gaacacacct ctgaataatg gccaaaggtg ggtgggtttc   4740

tctgaggaac gggcagcgtt tgcctctgaa agcaaggagc tctgcggagt tgcagttatt   4800

ttgcaactga tggtggaact ggtgcttaaa gcagattccc taggttccct gctacttctt   4860

ttccttcttg gcagtcagtt tatttctgac agacaaacag ccacccccac tgcaggctta   4920

gaaagtatgt ggctctgcct gggtgtgtta cagctctgcc ctggtgaaag gggattaaaa   4980

cgggcaccat tcatcccaaa caggatcctc attcatggat caagctgtaa ggaacttggg   5040

ctccaacctc aaaacattaa ttggagtacg aatgtaatta aaactgcatt ctcgcattcc   5100

taagtcattt agtctggact ctgcagcatg taggtcggca gctcccactt tctcaaagac   5160

cactgatgga ggagtagtaa aaatggagac cgattcagaa caaccaacgg agtgttgccg   5220

aagaaactga tggaaataat gcatgaattg tgtggtggac atttttttta aatacataaa   5280

ctacttcaaa tgaggtcgga gaaggtcagt gttttattag cagccataaa accaggtgag   5340

cgagtaccat ttttctctac aagaaaaacg attctgagct ctgcgtaagt ataagttctc   5400

catagcggct gaagctcccc cctggctgcc tgccatctca gctggagtgc agtgccattt   5460

ccttggggtt tctctcacag cagtaatggg acaatacttc acaaaaattc tttcttttcc   5520

tgtcatgtgg gatccctact gtgccctcct ggttttacgt taccccctga ctgttccatt   5580

cagcggtttg gaaagagaaa aagaatttgg aaataaaaca tgtctacgtt atcacctcct   5640

ccagcatttt ggtttttaat tatgtcaata actggcttag atttggaaat gagagggggt   5700

tgggtgtatt accgaggaac aaaggaaggc ttatataaac tcaagtcttt tatttagaga   5760

actggcaagc tgtcaaaaac aaaaaggcct taccaccaaa ttaagtgaat agccgctata   5820

gccagcaggg ccagcacgag ggatggtgca ctgctggcac tatgccacgg cctgcttgtg   5880

actctgagag caactgcttt ggaaatgaca gcacttggtg caatttcctt tgtttcagaa   5940

tgcgtagagc gtgtgcttgg cgacagtttt tctagttagg ccacttcttt tttccttctc   6000

tcctcattct cctaagcatg tctccatgct ggtaatccca gtcaagtgaa cgttcaaaca   6060

atgaatccat cactgtagga ttctcgtggt gatcaaatct ttgtgtgagg tctataaaat   6120

atggaagctt atttattttt cgttcttcca tatcagtctt ctctatgaca attcacatcc   6180

accacagcaa attaaaggtg aaggaggctg gtgggatgaa gagggtcttc tagctttacg   6240

ttcttccttg caaggccaca ggaaaatgct gagagctgta gaatacagcc tggggtaaga   6300

agttcagtct cctgctggga cagctaaccg catcttataa ccccttctga gactcatctt   6360

aggaccaaat agggtctatc tggggttttt gttcctgctg ttcctcctgg aaggctatct   6420

cactatttca ctgctcccac ggttacaaac caaagataca gcctgaattt tttctaggcc   6480

acattacata aatttgacct ggtaccaata ttgttctcta tatagttatt tccttcccca   6540

ctgtgtttaa ccccttaagg cattcagaac aactagaatc atagaatggt ttggattgga   6600

aggggcctta aacatcatcc atttccaacc ctctgccatg ggctgcttgc cacccactgg   6660

ctcaggctgc ccagggcccc atccagcctg gccttgagca cctccaggga tggggcaccc   6720

acagcttctc tgggcagcct gtgccaacac ctcaccactc tctgggtaaa gaattctctt   6780

ttaacatcta atctaaatct cttctctttt agtttaaagc cattcctctt tttcccgttg   6840

ctatctgtcc aagaaatgtg tattggtctc cctcctgctt ataagcagga agtactggaa   6900

ggctgcagtg aggtctcccc acagccttct cttctccagg ctgaacaagc ccagctcctt   6960

cagcctgtct tcgtaggaga tcatcttagt ggccctcctc tggacccatt ccaacagttc   7020

cacggctttc ttgtggagcc ccaggtctgg atgcagtact tcagatgggg ccttacaaag   7080

gcagagcaga tggggacaat cgcttacccc tccctgctgg ctgcccctgt tttgatgcag   7140

cccagggtac tgttggcctt tcaggctccc agaccccttg ctgatttgtg tcaagctttt   7200

catccaccag aacccacgct tcctggttaa tacttctgcc ctcacttctg taagcttgtt   7260

tcaggagact tccattcttt aggacagact gtgttacacc tacctgccct attcttgcat   7320

atatacattt cagttcatgt ttcctgtaac aggacagaat atgtattcct ctaacaaaaa   7380

tacatgcaga attcctagtg ccatctcagt agggttttca tggcagtatt agcacatagt   7440

caatttgctg caagtacctt ccaagctgcg gcctcccata aatcctgtat ttgggatcag   7500

ttaccttttg gggtaagctt ttgtatctgc agagaccctg ggggttctga tgtgcttcag   7560

ctctgctctg ttctgactgc accattttct agatcaccca gttgttcctg tacaacttcc   7620

ttgtcctcca tcctttccca gcttgtatct ttgacaaata caggcctatt tttgtgtttg   7680

cttcagcagc catttaattc ttcagtgtca tcttgttctg ttgatgccac tggaacagga   7740

ttttcagcag tcttgcaaag aacatctagc tgaaaacttt ctgccattca atattcttac   7800

cagttcttct tgtttgaggt gagccataaa ttactagaac ttcgtcactg acaagtttat   7860

gcattttatt acttctatta tgtacttact ttgacataac acagacacgc acatattttg   7920

ctgggatttc cacagtgtct ctgtgtcctt cacatggttt tactgtcata cttccgttat   7980

aaccttggca atctgcccag ctgcccatca caagaaaaga gattcctttt ttattacttc   8040

tcttcagcca ataaacaaaa tgtgagaagc ccaaacaaga acttgtgggg caggctgcca   8100

tcaagggaga gacagctgaa gggttgtgta gctcaataga attaagaaat aataaagctg   8160

tgtcagacag ttttgcctga tttatacagg cacgccccaa gccagagagg ctgtctgcca   8220

aggccacctt gcagtccttg gtttgtaaga taagtcatag gtaacttttc tggtgaattg   8280

cgtggagaat catgatggca gttcttgctg tttactatgg taagatgcta aaataggaga   8340

cagcaaagta acacttgctg ctgtaggtgc tctgctatcc agacagcgat ggcactcgca   8400

caccaagatg agggatgctc ccagctgacg gatgctgggg cagtaacagt gggtcccatg   8460

ctgcctgctc attagcatca cctcagccct caccagccca tcagaaggat catcccaagc   8520

tgaggaaagt tgctcatctt cttcacatca tcaaaccttt ggcctgactg atgcctcccg   8580

gatgcttaaa tgtggtcact gacatcttta tttttctatg atttcaagtc agaacctccg   8640

gatcaggagg gaacacatag tgggaatgta ccctcagctc caaggccaga tcttccttca   8700

atgatcatgc atgctactta ggaaggtgtg tgtgtgtgaa tgtagaattg cctttgttat   8760

tttttcttcc tgctgtcagg aacattttga ataccagaga aaaagaaaag tgctcttctt   8820

ggcatgggag gagttgtcac acttgcaaaa taaaggatgc agtcccaaat gttcataatc   8880

tcagggtctg aaggaggatc agaaactgtg tatacaattt caggcttctc tgaatgcagc   8940

ttttgaaagc tgttcctggc cgaggcagta ctagtcagaa ccctcggaaa caggaacaaa   9000

tgtcttcaag gtgcagcagg aggaaacacc ttgcccatca tgaaagtgaa taaccactgc   9060

cgctgaagga atccagctcc tgtttgagca ggtgctgcac actcccacac tgaaacaaca   9120

gttcattttt ataggacttc caggaaggat cttcttctta agcttcttaa ttatggtaca   9180

tctccagttg gcagatgact atgactactg acaggagaat gaggaactag ctgggaatat   9240

ttctgtttga ccaccatgga gtcacccatt tctttactgg tatttggaaa taataattct   9300

gaattgcaaa gcaggagtta gcgaagatct tcatttcttc catgttggtg acagcacagt   9360

tctggctatg aaagtctgct tacaaggaag aggataaaaa tcatagggat aataaatcta   9420

agtttgaaga caatgaggtt ttagctgcat ttgacatgaa gaaattgaga cctctactgg   9480

atagctatgg tatttacgtg tctttttgct tagttactta ttgaccccag ctgaggtcaa   9540

gtatgaactc aggtctctcg ggctactggc atggattgat tacatacaac tgtaatttta   9600

gcagtgattt agggtttatg agtacttttg cagtaaatca tagggttagt aatgttaatc   9660

tcagggaaaa aaaaaaaaag ccaaccctga cagacatccc agctcaggtg gaaatcaagg   9720

atcacagctc agtgcggtcc cagagaacac agggactctt ctcttaggac ctttatgtac   9780

agggcctcaa gataactgat gttagtcaga agactttcca ttctggccac agttcagctg   9840

aggcaatcct ggaattttct ctccgctgca cagttccagt catcccagtt tgtacagttc   9900

tggcactttt tgggtcaggc cgtgatccaa ggagcagaag ttccagctat ggtcagggag   9960

tgcctgaccg tcccaactca ctgcactcaa acaaaggcga aaccacaaga gtggcttttg  10020

ttgaaattgc agtgtggccc agaggggctg caccagtact ggattgacca cgaggcaaca  10080

ttaatcctca gcaagtgcaa tttgcagcca ttaaattgaa ctaactgata ctacaatgca  10140

atcagtatca acaagtggtt tggcttggaa gatggagtct aggggctcta caggagtagc  10200

tactctctaa tggagttgca ttttgaagca ggacactgtg aaaagctggc ctcctaaaga  10260

ggctgctaaa cattagggtc aattttccag tgcactttct gaagtgtctg cagttcccca  10320

tgcaaagctg cccaaacata gcacttccaa ttgaatacaa ttatatgcag gcgtactgct  10380

tcttgccagc actgtccttc tcaaatgaac tcaacaaaca atttcaaagt ctagtagaaa  10440

gtaacaagct ttgaatgtca ttaaaaagta tatctgcttt cagtagttca gcttatttat  10500

gcccactaga aacatcttgt acaagctgaa cactggggct ccagattagt ggtaaaacct  10560

actttataca atcatagaat catagaatgg cctgggttgg aagggacccc aaggatcatg  10620

aagatccaac acccccgcca caggcagggc caccaacctc cagatctggt actagaccag  10680

gcagcccagg gctccatcca acctggccat gaacacctcc agggatggag catccacaac  10740

ctctctgggc agcctgtgcc agcacctcac caccctctct gtgaagaact tttccctgac  10800

atccaatcta agccttccct ccttgaggtt agatccactc ccccttgtgc tatcactgtc  10860

tactcttgta aaaagttgat tctcctcctt tttggaaggt tgcaatgagg tctccttgca  10920

gccttcttct cttctgcagg atgaacaagc ccagctccct cagcctgtct ttataggaga  10980

ggtgctccag ccctctgatc atctttgtgg ccctcctctg gacccgctcc aagagctcca  11040

catctttcct gtactggggg ccccaggcct gaatgcagta ctccagatgg ggcctcaaaa  11100

gagcagagta aagagggaca atcaccttcc tcaccctgct ggccagccct cttctgatgg  11160

agccctggat acaactggct ttctgagctg caacttctcc ttatcagttc cactattaaa  11220

acaggaacaa tacaacaggt gctgatggcc agtgcagagt ttttcacact tcttcatttc  11280

ggtagatctt agatgaggaa cgttgaagtt gtgcttctgc gtgtgcttct tcctcctcaa  11340

atactcctgc ctgatacctc accccacctg ccactgaatg gctccatggc cccctgcagc  11400

cagggccctg atgaacccgg cactgcttca gatgctgttt aatagcacag tatgaccaag  11460

ttgcacctat gaatacacaa acaatgtgtt gcatccttca gcacttgaga agaagagcca  11520

aatttgcatt gtcaggaaat ggtttagtaa ttctgccaat taaaacttgt ttatctacca  11580

tggctgtttt tatggctgtt agtagtggta cactgatgat gaacaatggc tatgcagtaa  11640

aatcaagact gtagatattg caacagacta taaaattcct ctgtggctta gccaatgtgg  11700

tacttcccac attgtataag aaatttggca agtttagagc aatgtttgaa gtgttgggaa  11760

atttctgtat actcaagagg gcgtttttga caactgtaga acagaggaat caaaaggggg  11820

tgggaggaag ttaaaagaag aggcaggtgc aagagagctt gcagtcccgc tgtgtgtacg  11880

acactggcaa catgaggtct ttgctaatct tggtgctttg cttcctgccc ctggctgcct  11940

taggg                                                              11945


<210>  13
<211>  29
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  BAC 26 Primer-1

<400>  13
gcggaattca aagaagaaag ctgaaaaac                                       29


<210>  14
<211>  29
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  BAC 26 Primer-2

<400>  14
gcgggtacct tcaaatacta caagtgaaa                                       29


<210>  15
<211>  33
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  BAC 26-OV Primer 1

<400>  15
ggcctcgagt caagttctga gtaggtttta gtg                                  33


<210>  16
<211>  41
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  BAC 26-OV Primer 2

<400>  16
gcgcgtctct gtctagagca aacagcagaa cagtgaaaat g                         41


<210>  17
<211>  50
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CTLA-4-Fc Primer 1

<400>  17
gcgcgtctca agacaactca gagttcacca tgggtgtact gctcacacag                50


<210>  18
<211>  29
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CTLA-4-Fc Primer 2

<400>  18
ggcccgggag ttttgtcaga agatttggg                                       29


<210>  19
<211>  11868
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  pSIN-OV-3.5-I-CTLA4-inv Vector

<400>  19
aattgctaga ctaggatccc ccgtgctgca gaaccgagcg gctattgact tcttgctcct     60

agctcacggc catggctgtg aggacattgc gggaatgtgt tgtttcaatc tgagtgatca    120

cagtgagtct atacagaaga agttccagct aatgaaggaa catgtcaata agatcggcgt    180

gaacaacgac ccaatcggaa gttggctgcg aggattattc ggaggaatag gagaatgggc    240

cgtacacttg ctgaaaggac tgcttttggg gcttgtagtt atcttgttgc tagtagtatg    300

cttgccttgc cttttgcaat gtgtatctag tagtattcga aagatgattg ataattcact    360

cggctatcgc gaggaatata aaaaaattac aggaggctta taagcagccc gaaagaagag    420

cgtaggcgag ttcttgtatt ccgtgtgata gctggttgga ttggtaattg atcggctggc    480

acgcggaata taggaggtcg ctgaatagta aacttgtaga cttggctaca gcatagagta    540

tcttctgtag ctctgatgac tgctaggaaa taatgctacg gataatgtgg ggagggcaag    600

gcttgcgaat cgggttgtaa cgggcaaggc ttgactgagg ggacaatagc atgtttaggc    660

gaaaagcggg gcttcggttg tacgcggtta ggagtcccct caggatatag tagtttcgct    720

tttgcatagg gagggggacg gattggacga accactgaat tccgcattgc agagatattg    780

tatttaagtg cctagctcga tacaataaac gccatttgac cattcaccac attggtgtgc    840

acctgggttg atggccggac cgttgattcc ctgrcgacta cgagcacatg catgaagcag    900

aaggcttcat ttggtgaccc cgacgtgatc gttagggaat acgcgctcac tggccgtcgt    960

tttacaacgt cgtgactggg aaaaccctgg cgttacccaa cttaatcgcc ttgcagcaca   1020

tccccctttc gccagctggc gtaatagcga agaggcccgc accgatcgcc cttcccaaca   1080

gttgcgcagc ctgaatggcg aatggaaatt gtaagcgtta atattttgtt aaaattcgcg   1140

ttaaattttt gttaaatcag ctcatttttt aaccaatagg ccgaaatcgg caaaatccct   1200

tataaatcaa aagaatagac cgagataggg ttgagtgttg ttccagtttg gaacaagagt   1260

ccactattaa agaacgtgga ctccaacgtc aaagggcgaa aaaccgtcta tcagggcgat   1320

ggcccactac gtgaaccatc accctaatca agttttttgg ggtcgaggtg ccgtaaagca   1380

ctaaatcgga accctaaagg gagcccccga tttagagctt gacggggaaa gccggcgaac   1440

gtggcgagaa aggaagggaa gaaagcgaaa ggagcgggcg ctagggcgct ggcaagtgta   1500

gcggtcacgc tgcgcgtaac caccacaccc gccgcgctta atgcgccgct acagggcgcg   1560

tcaggtggca cttttcgggg aaatgtgcgc ggaaccccta tttgtttatt tttctaaata   1620

cattcaaata tgtatccgct catgagacaa taaccctgat aaatgcttca ataatattga   1680

aaaaggaaga gtatgagtat tcaacatttc cgtgtcgccc ttattccctt ttttgcggca   1740

ttttgccttc ctgtttttgc tcacccagaa acgctggtga aagtaaaaga tgctgaagat   1800

cagttgggtg cacgagtggg ttacatcgaa ctggatctca acagcggtaa gatccttgag   1860

agttttcgcc ccgaagaacg ttttccaatg atgagcactt ttaaagttct gctatgtggc   1920

gcggtattat cccgtattga cgccgggcaa gagcaactcg gtcgccgcat acactattct   1980

cagaatgact tggttgagta ctcaccagtc acagaaaagc atcttacgga tggcatgaca   2040

gtaagagaat tatgcagtgc tgccataacc atgagtgata acactgcggc caacttactt   2100

ctgacaacga tcggaggacc gaaggagcta accgcttttt tgcacaacat gggggatcat   2160

gtaactcgcc ttgatcgttg ggaaccggag ctgaatgaag ccataccaaa cgacgagcgt   2220

gacaccacga tgcctgtagc aatggcaaca acgttgcgca aactattaac tggcgaacta   2280

cttactctag cttcccggca acaattaata gactggatgg aggcggataa agttgcagga   2340

ccacttctgc gctcggccct tccggctggc tggtttattg ctgataaatc tggagccggt   2400

gagcgtgggt ctcgcggtat cattgcagca ctggggccag atggtaagcc ctcccgtatc   2460

gtagttatct acacgacggg gagtcaggca actatggatg aacgaaatag acagatcgct   2520

gagataggtg cctcactgat taagcattgg taactgtcag accaagttta ctcatatata   2580

ctttagattg atttaaaact tcatttttaa tttaaaagga tctaggtgaa gatccttttt   2640

gataatctca tgaccaaaat cccttaacgt gagttttcgt tccactgagc gtcagacccc   2700

gtagaaaaga tcaaaggatc ttcttgagat cctttttttc tgcgcgtaat ctgctgcttg   2760

caaacaaaaa aaccaccgct accagcggtg gtttgtttgc cggatcaaga gctaccaact   2820

ctttttccga aggtaactgg cttcagcaga gcgcagatac caaatactgt ccttctagtg   2880

tagccgtagt taggccacca cttcaagaac tctgtagcac cgcctacata cctcgctctg   2940

ctaatcctgt taccagtggc tgctgccagt ggcgataagt cgtgtcttac cgggttggac   3000

tcaagacgat agttaccgga taaggcgcag cggtcgggct gaacgggggg ttcgtgcaca   3060

cagcccagct tggagcgaac gacctacacc gaactgagat acctacagcg tgagctatga   3120

gaaagcgcca cgcttcccga agggagaaag gcggacaggt atccggtaag cggcagggtc   3180

ggaacaggag agcgcacgag ggagcttcca gggggaaacg cctggtatct ttatagtcct   3240

gtcgggtttc gccacctctg acttgagcgt cgatttttgt gatgctcgtc aggggggcgg   3300

agcctatgga aaaacgccag caacgcggcc tttttacggt tcctggcctt ttgctggcct   3360

tttgctcaca tgttctttcc tgcgttatcc cctgattctg tggataaccg tattaccgcc   3420

tttgagtgag ctgataccgc tcgccgcagc cgaacgaccg agcgcagcga gtcagtgagc   3480

gaggaagcgg aagagcgccc aatacgcaaa ccgcctctcc ccgcgcgttg gccgattcat   3540

taatgcagct ggcacgacag gtttcccgac tggaaagcgg gcagtgagcg caacgcaatt   3600

aatgtgagtt agctcactca ttaggcaccc caggctttac actttatgct tccggctcgt   3660

atgttgtgtg gaattgtgag cggataacaa tttcacacag gaaacagcta tgaccatgat   3720

tacgccaagc gcgcattggt aattgatcgg ctggcacgcg gaatatagga ggtcgctgaa   3780

tagtaaactt gtagacttgg ctacagcata gagtatcttc tgtagctctg atgactgcta   3840

ggaaataatg ctacggataa tgtggggagg gcaaggcttg cgaatcgggt tgtaacgggc   3900

aaggcttgac tgaggggaca atagcatgtt taggcgaaaa gcggggcttc ggttgtacgc   3960

ggttaggagt cccctcagga tatagtagtt tcgcttttgc atagggaggg ggaaatgtag   4020

tcttatgcaa tactcttgta gtcttgcaac atgcttatgt aacgatgagt tagcaacatg   4080

ccttataagg agagaaaaag caccgtgcat gccgattggt gggagtaagg tggtatgatc   4140

gtggtatgat cgtgccttgt taggaaggca acagacgggt ctaacacgga ttggacgaac   4200

cactgaattc cgcattgcag agatattgta tttaagtgcc tagctcgata caataaacgc   4260

catttgacca ttcaccacat tggtgtgcac ctgggttgat ggccggaccg ttgattccct   4320

grcgactacg agcacatgca tgaagcagaa ggcttcattt ggtgaccccg acgtgatcgt   4380

tagggaatag tggtcggcca caggcggcgt ggcgatcctg tcctcatccg tctcgcttat   4440

tcggggagcg gacgatgacc ctagtagagg gggctgcggc ttaggagggc agaagctgag   4500

tggcgtcgga gggagcccta ctgcaggggg ccaacatacc ctaccgagaa ctcagagagt   4560

cgttggaaga cgggaaggaa gcccgacgac tgagcggtcc accccaggcg tgattccggt   4620

tgctctgcgt gattccggtc gcccggtgga tcaagcatgg aagccgtcat aaaggtgatt   4680

tcgtccgcgt gtaagaccta ttgcgggaaa acctctcctt ctaagaagga aataggggct   4740

atgttgtccc tgttacaaaa ggaagggttg cttacgtccc cctcagactt atattccccg   4800

gggtcctggg atcccattac cgcggcgctc tctcagcggg ctatggtact tggaaaatcg   4860

ggagagttaa aaacctgggg attggttttg ggggcattga aggcggctcg agatccggta   4920

ccttcaaata ctacaagtga aaagtgtttg cttaaacatg tttttattat gattaaagga   4980

acaaaagagc acattcacaa gacccattac atatgggtac aaggaaaaca atttgaatag   5040

taatatacca tatttgccaa cataccatga ttgagtcaaa gtttagggag aaatgtgaat   5100

tataagattt ttataatgca tctttaggaa gtcaggaaga gccttgtagt atcaggaaca   5160

cagagaacaa gcaattgcct tgtcagcata ggaatggttg gtgacagttg ataatttaat   5220

ctgagagatt ttgagtgact aattctggag cagcttggtc atacagatat ctggcttaat   5280

tggaaggctg catttttccc ccataaacct tctgctgatg tatcaggttg catttttcag   5340

tgtgatgact cagtactgtg agtccaattt cattccctta agccttcatc catgagttac   5400

cagtattact ctgtgtaaag gaaaagtgaa ttgcacctgt tctcacagtg taatttcttt   5460

ctgatttttt ttctagatta agctccagct tttatgaagt ctggatgcag cagataacat   5520

acttttcatt ttacccctga tactacagtg ctctgggtct tgttggaagg gacagagttt   5580

ttcagctttc ttctttgaat tcctcattta cccggagaca gggagaggct cttctgcgtg   5640

tagtggttgt gcagagcctc atgcatcacg gagcatgaga agacgttccc ctgctgccac   5700

ctgctcttgt ccacggtgag cttgctgtag aggaagaagg agccgtcgga gtccagcacg   5760

ggaggcgtgg tcttgtagtt gttctccggc tgcccattgc tctcccactc cacggcgatg   5820

tcgctgggat agaagccttt gaccaggcag gtcaggctga cctggttctt ggtcagctca   5880

tcccgggatg ggggcagggt gtacacctgt ggttctcggg gctgcccttt ggctttggag   5940

atggttttct cgatgggggc tgggagggct ttgttggaga ccttgcactt gtactccttg   6000

ccattcagcc agtcctggtg caggacggtg aggacgctga ccacccggta cgtgctgttg   6060

tactgctcct cccgcggctt tgtcttggca ttatgcacct ccacgccgtc cacgtaccag   6120

ttgaacttga cctcagggtc ttcgtggctc acgtccacca ccacgcatgt gacctcaggg   6180

gtccgggaga tcatgagggt gtccttgggt tttgggggga agaggaagac tgacgatccc   6240

cccaggagtt caggtgctgg ggacggtggg gatgtgtgag ttttgtcaga agatttgggc   6300

tcctgatcag aatctgggca cggttctgga tcaattacat aaatctgggt tccgttgcct   6360

atgcccaggt agtatggcgg tgggtacatg agctccacct tgcagatgta gagtcccgtg   6420

tccatggccc tcagtccttg gatagtgagg ttcacttgat ttccactgga ggtgcccgtg   6480

cagatggaat catctaggaa ggtcaactca ttccccatca tgtaggttgc cgcacagact   6540

tcagtcacct ggctgtcagc ctgccgaagc actgtcaccc ggacctcagt ggctttgcct   6600

ggagatgcat actcacacac aaagctrgcg atgcctcggc tgctggccag taccacagca   6660

ggctgggcca cgtgcattgc catgctcgcc atgcttggaa acaggagtgc aaggaccaga   6720

ctgagcagcg tcctctgtgt gagcagtaca cccatggtga actctgagtt gtctagagca   6780

aacagcagaa cagtgaaaat gtaaggatgg aatgctgtac atagtaccat gcagggtact   6840

ctatggtagg ctacaacagt aaattacgag cagtttttag gcaattaaat gttaacaagt   6900

agttttaaag taattctgtg gtaatgtgtc tgttgctata tccacctctc atgtgcatgt   6960

tcaaaaccat attcataaat ctatttatgt atttgcattc agttgtcttt tgggtagcaa   7020

actgtcccag aagccagttg cctctacata tttttgttca gtgaaagcta gaattcattg   7080

atacttttca gtacctctga ttaaaacaca atctgatagg cttgcaaaac tggaaattca   7140

aagagcaaat ttcagtaaac tttaggtttg gacagatata tgagaaagca gaggcttgct   7200

gactatttta tttcttattt ttattcccta aaaataaatg tagagaaata tctgtttgtt   7260

gcacactact tgctatgagt agatcttcaa aagtattttt acctttgttt tggtgatggc   7320

agaatagata aggaatgtaa tttatatggg gtcatgtagt ctaggagaaa gacacgcatg   7380

taattcatat tctgctctat tgcactttca ggtatggttt gctttgctca aagatatgca   7440

tgtgtactgt agtataaact ttctgtggag ttaaatttta gtggtgacat tcagacagaa   7500

gagaaatgca gacatgataa aatagcaatg tttactataa aacagagcca ctgaatgaat   7560

tcttgttcat gacatagacc aatagaagat ttatacttgt tctgtctgtt tctattataa   7620

agagctgaac tgtacaacta ttgtatagcc agtgtgctta tataaagcac agcttttgga   7680

gccagcatga atctagttgc tttcctgaga tttatataat ctgtgaaagt cagaagtcct   7740

tcagagccca gccctttata tgcgtactga gtgctggggc ctcaggattg gattttctgt   7800

attaaacccc tcaaaagttt ttactgacca cgtgtgtgag tatacacaca cacatttttc   7860

tcattttctt ttctgtatat aagttcacat gtatctatta ttgtaagaat atacgtttat   7920

gcacccccca catttttatc ttgtgtagtg atcagcagct gcactttgca ggaattaaac   7980

ttctagagaa ttttcacatt aaaataactc cccagaattc actgaacacc atgattttgc   8040

tctctgtgca ctctgtaggg ctagaagtta atcaagcaaa ctgcaaagca tatcagatag   8100

tgaacgacag gataagatgt tctgaaatta aaaacatatt ttaagcacaa agaataagcc   8160

tcctgaaaac aaacacaaag cttttacaca taataaaata gtgcagaatg catacacagg   8220

tgagaagttt ttataggggg tatcacgcag gtacttcacc cttaaagata caacacatag   8280

cacaataatt gttaattttt taaagtttag gtgcaagtaa gagctaatat agagagaagg   8340

taattccaga gagttgctta cctttcgagc ttgactgcta aaggcaatac agctttctag   8400

ctgtatgtac agacactggc tgagccctgg ggaatatata gtctgaattg tgacccaccc   8460

acaggttccc ttcagaagtt tgacctttga caccatagaa atcatttaat gggattgggt   8520

tagattttag tttcaatagg tccattttgg attgaatgga gagcaaatat tagtttttaa   8580

ttctgggtaa caatgtgttt tctgcctgtt ctgctaatcc atcaggactg ttggatggga   8640

gagaagactg ggaaatattg ctcatgttcc attgagcttc agttacaacc agataatggg   8700

atctttaaga aaacagaaaa atgtgggaac cttggagatg gaaaacataa ttagcaatta   8760

ttagttagtg tgcttattac tatggttgta gtaacagacc agaagtctgt ttcatttgat   8820

ccttcttgta tgtacaatgt gcatctgagc cacgctagac aggacataaa tgagaacaag   8880

acttgaccta ttattttctt gacaaaatag gagaaataaa gaagcgtgca tgtgaaggag   8940

ccaactgaga ctagagtgaa gagcagacac actttctttc ctatagttgg aatatttaaa   9000

tctatctttt tatgggtgtg aatgctttat aacaaacttt tattctgagg atacagcaaa   9060

acatagctcc atacaatgca aaacaatact caatttcaaa tgtgtttatg atatgaactt   9120

gcagtgttcc tcaaagatct tccatgaata acttaatggc ctggcagatg acagaggaat   9180

tgtgaaattc agctggagga gtgttcatgg ttcgagggac aatcataata tacaatagca   9240

aatatatttc agttatagaa gctattgttc tgtattgaaa taatagaatt gacaaacagt   9300

aaagaaacca ttctgacctc tgtaaagcac tgtttgattt aaaaatgggg gaaaaaagta   9360

caacataatt cttcaggaca tacatagaga tcactgcaat ctctgttaag cagaattact   9420

ttcctatacc actagctgaa gtttagtcag tgccattttc ttttgtttct ctccttcctt   9480

ttgtgaaaac atatatactg tggaaatcta cattctcctt gccaagtctg aggacttaag   9540

acaagatggt agtgcaaata atattttttt gctggatgtc tacaccacag gtatcaactg   9600

attttttttg tttcattttg tttttaatca cgtcttttgc ttctatttca gccactaaga   9660

aagtctgaaa atcttgcctg ctttttgtga tgatagatgt gcttcccagt aaatgttatc   9720

tctacctatg aaatgcatgt cagtctgcag aaagagaaag gagattggga ataggttttc   9780

tcagatgcac ttctctgtca tctggtgtca atcaaacact aataatttgt gtatagatat   9840

cttatatata tatatatatt tggaatttgc aggttggcat agttcagata gtcctgtcac   9900

attgtaatat cctggtgaga taacaaggaa aagagagacc gtttcggctc ttactaaggc   9960

agggaactgc ttaccagaca gggaggttct ggagatgaca tccagcatga aaagcacact  10020

tccaaatact taaaggtatc aagtctaact tgtcagacag gctccagaat aacttctgtc  10080

ctaatgctac agaaaagggg gaaggtatcc accatggcca aaattgtcag ccattttgtc  10140

tcagcaaaca gcagatctgg tcagtaagga caagattctt ccaaagcaac catgccatat  10200

ataattaagc atgtgtaatt aattaataaa aaatataatt tagtgtattt cctcctttgg  10260

atgttatgaa gaaatgcttt tattaacaat tcaccataat ctgtcctaag agtagtgaat  10320

aacaacaggc tgcttctcac cctgtggttg ggtgtaccag tgagccagag ctaaacgcca  10380

cgtttcctct tttgtatccc atagcagaga gggtctccat ttcatttctg tagctcagaa  10440

agttgtagtg gatttacact acaagttgtg gtagtggagg tctgccggag tggcctctgt  10500

gaacagagcc cagcagctgt cccgtgtcct caaaagggag ctgccactgg ccagagctga  10560

gccagtgatc gatgctagat gtacctcagg aggagcaata tgtaagaaca actgctgtac  10620

aatggtagtt gggagaggtg agtgagaaaa tgtgagagaa acagccctga tgacactgag  10680

gtcagtgcgg aggagggcag gaggtgttcc aggtgtagaa cagaagttcc ctgcagccca  10740

agagaggccc atggtggagc actctgaccc tctgcagccc atggtatatc atataaacct  10800

cagttctgtg acattatttt aactccatat cccttttctg ttcagggtca ctttgagttc  10860

acagccattt ctttatattt ctccaatatc agccttccat tgctacatat gagacttgga  10920

cagtacatct gattcagtca aatctgcctt cagaacgtcc ctgaagccct tcttagacag  10980

tctcaattct ccttcccttc atctctttta tcatacatgg accacggacc tgtccagacc  11040

tgagtcatat gtccatcttt acgtccatct ctatgtcttg tactttaaga caaataaaat  11100

atcaaggaaa ttgatgcagt tatgtcagtt atcactgtca tagtatcgtg ctgcaaatat  11160

aagatgagaa tgatcccaaa ggctttttaa agctgctcta tttgacttcc acatagtgtc  11220

ctgattccag acctacagaa cagttttgta tgcatttgac ttgcagagct ttgttttgtg  11280

agtcttataa aagccatttt tcctctccaa gaagtagccg gtggtttaaa acaatgtaga  11340

ttaagtgtgg agcatgagaa tttctgcttt tctgtcagat gagaaggata tactacactc  11400

tttcccaatg gaagaccagc tgcaagcaac aaaaattgtc catgaacaaa tgagatcttg  11460

atcagaacag gctgtcatca tagtgttgtc agcatacctg catagttggt ttgacttggg  11520

ggtctagaga gagtaagcaa caatcttctt gcagttggaa ggttacctgg gataggtggc  11580

aatggattgc cctgcccagc acagctgtgc aaagcagtac aaatagtttt gtcacacatt  11640

gtttgacaat gcttgtccca agaaaaggtc agctaaggct ctgctgccct ttcctatgcc  11700

aggcatttca ttgtgggtct gtccctaaac caacagtctc atgaataaag actcggagac  11760

ctgaaagtta taaaagcact ttttatccaa aaggatatga agtccaggtg agctcacagg  11820

tcaaagcctc ttatccaatc actaaaacct actcagaact tgactcga               11868


<210>  20
<211>  10021
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  pSIN-3.9-OM-CTLA4-Fc Vector

<400>  20
ctagactagg atcccccgtg ctgcagaacc gagcggctat tgacttcttg ctcctagctc     60

acggccatgg ctgtgaggac attgcgggaa tgtgttgttt caatctgagt gatcacagtg    120

agtctataca gaagaagttc cagctaatga aggaacatgt caataagatc ggcgtgaaca    180

acgacccaat cggaagttgg ctgcgaggat tattcggagg aataggagaa tgggccgtac    240

acttgctgaa aggactgctt ttggggcttg tagttatctt gttgctagta gtatgcttgc    300

cttgcctttt gcaatgtgta tctagtagta ttcgaaagat gattgataat tcactcggct    360

atcgcgagga atataaaaaa attacaggag gcttataagc agcccgaaag aagagcgtag    420

gcgagttctt gtattccgtg tgatagctgg ttggattggt aattgatcgg ctggcacgcg    480

gaatatagga ggtcgctgaa tagtaaactt gtagacttgg ctacagcata gagtatcttc    540

tgtagctctg atgactgcta ggaaataatg ctacggataa tgtggggagg gcaaggcttg    600

cgaatcgggt tgtaacgggc aaggcttgac tgaggggaca atagcatgtt taggcgaaaa    660

gcggggcttc ggttgtacgc ggttaggagt cccctcagga tatagtagtt tcgcttttgc    720

atagggaggg ggacggattg gacgaaccac tgaattccgc attgcagaga tattgtattt    780

aagtgcctag ctcgatacaa taaacgccat ttgaccattc accacattgg tgtgcacctg    840

ggttgatggc cggaccgttg attccctgrc gactacgagc acatgcatga agcagaaggc    900

ttcatttggt gaccccgacg tgatcgttag ggaatacgcg ctcactggcc gtcgttttac    960

aacgtcgtga ctgggaaaac cctggcgtta cccaacttaa tcgccttgca gcacatcccc   1020

ctttcgccag ctggcgtaat agcgaagagg cccgcaccga tcgcccttcc caacagttgc   1080

gcagcctgaa tggcgaatgg aaattgtaag cgttaatatt ttgttaaaat tcgcgttaaa   1140

tttttgttaa atcagctcat tttttaacca ataggccgaa atcggcaaaa tcccttataa   1200

atcaaaagaa tagaccgaga tagggttgag tgttgttcca gtttggaaca agagtccact   1260

attaaagaac gtggactcca acgtcaaagg gcgaaaaacc gtctatcagg gcgatggccc   1320

actacgtgaa ccatcaccct aatcaagttt tttggggtcg aggtgccgta aagcactaaa   1380

tcggaaccct aaagggagcc cccgatttag agcttgacgg ggaaagccgg cgaacgtggc   1440

gagaaaggaa gggaagaaag cgaaaggagc gggcgctagg gcgctggcaa gtgtagcggt   1500

cacgctgcgc gtaaccacca cacccgccgc gcttaatgcg ccgctacagg gcgcgtcagg   1560

tggcactttt cggggaaatg tgcgcggaac ccctatttgt ttatttttct aaatacattc   1620

aaatatgtat ccgctcatga gacaataacc ctgataaatg cttcaataat attgaaaaag   1680

gaagagtatg agtattcaac atttccgtgt cgcccttatt cccttttttg cggcattttg   1740

ccttcctgtt tttgctcacc cagaaacgct ggtgaaagta aaagatgctg aagatcagtt   1800

gggtgcacga gtgggttaca tcgaactgga tctcaacagc ggtaagatcc ttgagagttt   1860

tcgccccgaa gaacgttttc caatgatgag cacttttaaa gttctgctat gtggcgcggt   1920

attatcccgt attgacgccg ggcaagagca actcggtcgc cgcatacact attctcagaa   1980

tgacttggtt gagtactcac cagtcacaga aaagcatctt acggatggca tgacagtaag   2040

agaattatgc agtgctgcca taaccatgag tgataacact gcggccaact tacttctgac   2100

aacgatcgga ggaccgaagg agctaaccgc ttttttgcac aacatggggg atcatgtaac   2160

tcgccttgat cgttgggaac cggagctgaa tgaagccata ccaaacgacg agcgtgacac   2220

cacgatgcct gtagcaatgg caacaacgtt gcgcaaacta ttaactggcg aactacttac   2280

tctagcttcc cggcaacaat taatagactg gatggaggcg gataaagttg caggaccact   2340

tctgcgctcg gcccttccgg ctggctggtt tattgctgat aaatctggag ccggtgagcg   2400

tgggtctcgc ggtatcattg cagcactggg gccagatggt aagccctccc gtatcgtagt   2460

tatctacacg acggggagtc aggcaactat ggatgaacga aatagacaga tcgctgagat   2520

aggtgcctca ctgattaagc attggtaact gtcagaccaa gtttactcat atatacttta   2580

gattgattta aaacttcatt tttaatttaa aaggatctag gtgaagatcc tttttgataa   2640

tctcatgacc aaaatccctt aacgtgagtt ttcgttccac tgagcgtcag accccgtaga   2700

aaagatcaaa ggatcttctt gagatccttt ttttctgcgc gtaatctgct gcttgcaaac   2760

aaaaaaacca ccgctaccag cggtggtttg tttgccggat caagagctac caactctttt   2820

tccgaaggta actggcttca gcagagcgca gataccaaat actgtccttc tagtgtagcc   2880

gtagttaggc caccacttca agaactctgt agcaccgcct acatacctcg ctctgctaat   2940

cctgttacca gtggctgctg ccagtggcga taagtcgtgt cttaccgggt tggactcaag   3000

acgatagtta ccggataagg cgcagcggtc gggctgaacg gggggttcgt gcacacagcc   3060

cagcttggag cgaacgacct acaccgaact gagataccta cagcgtgagc tatgagaaag   3120

cgccacgctt cccgaaggga gaaaggcgga caggtatccg gtaagcggca gggtcggaac   3180

aggagagcgc acgagggagc ttccaggggg aaacgcctgg tatctttata gtcctgtcgg   3240

gtttcgccac ctctgacttg agcgtcgatt tttgtgatgc tcgtcagggg ggcggagcct   3300

atggaaaaac gccagcaacg cggccttttt acggttcctg gccttttgct ggccttttgc   3360

tcacatgttc tttcctgcgt tatcccctga ttctgtggat aaccgtatta ccgcctttga   3420

gtgagctgat accgctcgcc gcagccgaac gaccgagcgc agcgagtcag tgagcgagga   3480

agcggaagag cgcccaatac gcaaaccgcc tctccccgcg cgttggccga ttcattaatg   3540

cagctggcac gacaggtttc ccgactggaa agcgggcagt gagcgcaacg caattaatgt   3600

gagttagctc actcattagg caccccaggc tttacacttt atgcttccgg ctcgtatgtt   3660

gtgtggaatt gtgagcggat aacaatttca cacaggaaac agctatgacc atgattacgc   3720

caagcgcgca ttggtaattg atcggctggc acgcggaata taggaggtcg ctgaatagta   3780

aacttgtaga cttggctaca gcatagagta tcttctgtag ctctgatgac tgctaggaaa   3840

taatgctacg gataatgtgg ggagggcaag gcttgcgaat cgggttgtaa cgggcaaggc   3900

ttgactgagg ggacaatagc atgtttaggc gaaaagcggg gcttcggttg tacgcggtta   3960

ggagtcccct caggatatag tagtttcgct tttgcatagg gagggggaaa tgtagtctta   4020

tgcaatactc ttgtagtctt gcaacatgct tatgtaacga tgagttagca acatgcctta   4080

taaggagaga aaaagcaccg tgcatgccga ttggtgggag taaggtggta tgatcgtggt   4140

atgatcgtgc cttgttagga aggcaacaga cgggtctaac acggattgga cgaaccactg   4200

aattccgcat tgcagagata ttgtatttaa gtgcctagct cgatacaata aacgccattt   4260

gaccattcac cacattggtg tgcacctggg ttgatggccg gaccgttgat tccctgrcga   4320

ctacgagcac atgcatgaag cagaaggctt catttggtga ccccgacgtg atcgttaggg   4380

aatagtggtc ggccacaggc ggcgtggcga tcctgtcctc atccgtctcg cttattcggg   4440

gagcggacga tgaccctagt agagggggct gcggcttagg agggcagaag ctgagtggcg   4500

tcggagggag ccctactgca gggggccaac ataccctacc gagaactcag agagtcgttg   4560

gaagacggga aggaagcccg acgactgagc ggtccacccc aggcgtgatt ccggttgctc   4620

tgcgtgattc cggtcgcccg gtggatcaag catggaagcc gtcataaagg tgatttcgtc   4680

cgcgtgtaag acctattgcg ggaaaacctc tccttctaag aaggaaatag gggctatgtt   4740

gtccctgtta caaaaggaag ggttgcttac gtccccctca gacttatatt ccccggggtc   4800

ctgggatccc attaccgcgg cgctctctca gcgggctatg gtacttggaa aatcgggaga   4860

gttaaaaacc tggggattgg ttttgggggc attgaaggcg gctcgaggtc gacggtatcg   4920

ataagcttgc agtccaaggc tttgtctgtg tacccagtga aatccttcct ctgttacata   4980

aagcccagat aggactcaga aatgtagtca ttccagcccc cctcttcctc agatctggag   5040

cagcacttgt ttgcagccag tcctccccaa aatgcacaga cctcgccgag tggagggaga   5100

tgtaaacagc gaaggttaat tacctccttg tcaaaaacac tttgtggtcc atagatgttt   5160

ctgtcaatct tacaaaacag aaccgagagg cagcgagcac tgaagagcgt gttcccatgc   5220

tgagttaatg agacttggca gctcgctgtg cagagatgat ccctgtgctt catgggaggc   5280

tgtaacctgt ctccccatcg ccttcacacc gcagtgctgt cctggacacc tcaccctcca   5340

taagctgtag gatgcagctg cccagggatc aagagacttt tcctaaggct cttaggactc   5400

atctttgccg ctcagtagcg tgcagcaatt actcatccca actatactga atgggtttct   5460

gccagctctg cttgtttgtc aataagcatt tcttcatttt gcctctaagt ttctctcagc   5520

agcaccgctc tgggtgacct gagtggccac ctggaacccg aggggcacag ccaccacctc   5580

cctgttgctg ctgctccagg gactcatgtg ctgctggatg gggggaagca tgaagttcct   5640

cacccagaca cctgggttgc aatggctgca gcgtgctctt cttggtatgc agattgtttc   5700

cagccattac ttgtagaaat gtgctgtgga agccctttgt atctctttct gtggcccttc   5760

agcaaaagct gtgggaaagc tctgaggctg ctttcttggg tcgtggagga attgtatgtt   5820

ccttctttaa caaaaattat ccttaggaga gagcactgtg caagcattgt gcacataaaa   5880

caattcaggt tgaaagggct ctctggaggt ttccagcctg actactgctc gaagcaaggc   5940

caggttcaaa gatggctcag gatgctgtgt gccttcctga ttatctgtgc caccaatgga   6000

ggagattcac agccactctg cttcccgtgc cactcatgga gaggaatatt cccttatatt   6060

cagatagaat gttatccttt agctcagcct tccctataac cccatgaggg agctgcagat   6120

ccccatactc tccccttctc tggggtgaag gccgtgtccc ccagcccccc ttcccaccct   6180

gtgccctaag cagcccgctg gcctctgctg gatgtgtgcc tatatgtcaa tgcctgtcct   6240

tgcagtccag cctgggacat ttaattcatc accagggtaa tgtggaactg tgtcatcttc   6300

ccctgcaggg tacaaagttc tgcacggggt cctttcggtt caggaaaacc ttcactggtg   6360

ctacctgaat caagctctat ttaataagtt cataagcaca tggatgtgtt ttcctagaga   6420

tacgttttaa tggtatcagt gatttttatt tgctttgttg cttacttcaa acagtgcctt   6480

tgggcaggag gtgagggacg ggtctgccgt tggctctgca gtgatttctc caggcgtgtg   6540

gctcaggtca gatagtggtc actctgtggc cagaagaagg acaaagatgg aaattgcaga   6600

ttgagtcacg ttaagcaggc atcttggagt gatttgaggc agtttcatga aagagctacg   6660

accacttatt gttgttttcc ccttttacaa cagaagtttt catcaaaata acgtggcaaa   6720

gcccaggaat gtttgggaaa agtgtagtta aatgttttgt aattcatttg tcggagtgct   6780

accagctaag aaaaaagtcc tacctttggt atggtagtcc tgcagagaat acaacatcaa   6840

tattagtttg gaaaaaaaca ccaccaccac cagaaactgt aatggaaaat gtaaaccaag   6900

aaattccttg ggtaagagag aaaggatgtc gtatactggc caagtcctgc ccagctgtca   6960

gcctgctgac cctctgcagt tcaggaccat gaaacgtggc actgtaagac gtgtcccctg   7020

cctttgcttg cccacagatc tctgcccttg tgctgactcc tgcacacaag agcatttccc   7080

tgtagccaaa cagcgattag ccataagctg cacctgactt tgaggattaa gagtttgcaa   7140

ttaagtggat tgcagcagga gatcagtggc agggttgcag atgaaatcct tttctagggg   7200

tagctaaggg ctgagcaacc tgtcctacag cacaagccaa accagccaag ggttttcctg   7260

tgctgttcac agaggcaggg ccagctggag ctggaggagg ttgtgctggg acccttctcc   7320

ctgtgctgag aatggagtga tttctgggtg ctgttcctgt ggcttgcact gagcagctca   7380

agggagatcg gtgctcctca tgcagtgcca aaactcgtgt ttgatgcaga aagatggatg   7440

tgcacctccc tcctgctaat gcagccgtga gcttatgaag gcaatgagcc ctcagtgcag   7500

caggagctgt agtgcactcc tgtaggtgct agggaaaatc tctggttccc agggatgcat   7560

tcataagggc aatatatctt gaggctgcgc caaatctttc tgaaatattc atgcgtgttc   7620

ccttaattta tagaaacaaa cacagcagaa taattattcc aatgcctccc ctcgaaggaa   7680

acccatattt ccatgtagaa atgtaaccta tatacacaca gccatgctgc atccttcaga   7740

acgtgccagt gctcatctcc catggcaaaa tactacaggt attctcacta tgttggacct   7800

gtgaaaggaa ccatggtaag aaacttcggt taaaggtatg gctgcaaaac tactcatacc   7860

aaaacagcag agctccagac ctcctcttag gaaagagcca cttggagagg gatggtgtga   7920

aggctggagg tgagagacag agcctgtccc agttttcctg tctctatttt ctgaaacgtt   7980

tgcaggagga aaggacaact gtactttcag gcatagctgg tgccctcacg taaataagtt   8040

ccccgaactt ctgtgtcatt tgttcttaag atgctttggc agaacacttt gagtcaattc   8100

gcttaactgt gactaggtct gtaaataagt gctccctgct gataaggttc aagtgacatt   8160

tttagtggta tttgacagca tttaccttgc tttcaagtct tctaccaagc tcttctatac   8220

ttaagcagtg aaaccgccaa gaaacccttc cttttatcaa gctagtgcta aataccatta   8280

acttcatagg ttagatacgg tgctgccagc ttcacctggc agtggttggt cagttctgct   8340

ggtgacaaag cctccctggc ctgtgctttt acctagaggt gaatatccaa gaatgcagaa   8400

ctgcatggaa agcagagctg caggcacgat ggtgctgagc cttagctgct tcctgctggg   8460

agatgtggat gcagagacga atgaaggacc tgtcccttac tcccctcagc attctgtgct   8520

atttagggtt ctaccagagt ccttaagagg tttttttttt ttttggtcca aaagtctgtt   8580

tgtttggttt tgaccactga gagcatgtga cacttgtctc aagctattaa ccaagtgtcc   8640

agccaaaatc aattgcctgg gagacgcaga ccattacctg gaggtcagga cctcaataaa   8700

tattaccagc ctcattgtgc cgctgacaga ttcagctggc tgctccgtgt tccagtccaa   8760

cagttcggac gccacgtttg tatatatttg caggcagcct cggggggacc atctcaggag   8820

cagagcaccg gcagccgcct gcagagccgg gcagtacctc aacatgggtg tactgctcac   8880

acagaggacg ctgctcagtc tggtccttgc actcctgttt ccaagcatgg cgagcatggc   8940

aatgcacgtg gcccagcctg ctgtggtact ggccagcagc cgaggcatcg cyagctttgt   9000

gtgtgagtat gcatctccag gcaaagccac tgaggtccgg gtgacagtgc ttcggcaggc   9060

tgacagccag gtgactgaag tctgtgcggc aacctacatg atggggaatg agttgacctt   9120

cctagatgat tccatctgca cgggcacctc cagtggaaat caagtgaacc tcactatcca   9180

aggactgagg gccatggaca cgggactcta catctgcaag gtggagctca tgtacccacc   9240

gccatactac ctgggcatag gcaacggaac ccagatttat gtaattgatc cagaaccgtg   9300

cccagattct gatcaggagc ccaaatcttc tgacaaaact cacacatccc caccgtcccc   9360

agcacctgaa ctcctggggg gatcgtcagt cttcctcttc cccccaaaac ccaaggacac   9420

cctcatgatc tcccggaccc ctgaggtcac atgcgtggtg gtggacgtga gccacgaaga   9480

ccctgaggtc aagttcaact ggtacgtgga cggcgtggag gtgcataatg ccaagacaaa   9540

gccgcgggag gagcagtaca acagcacgta ccgggtggtc agcgtcctca ccgtcctgca   9600

ccaggactgg ctgaatggca aggagtacaa gtgcaaggtc tccaacaaag ccctcccagc   9660

ccccatcgag aaaaccatct ccaaagccaa agggcagccc cgagaaccac aggtgtacac   9720

cctgccccca tcccgggatg agctgaccaa gaaccaggtc agcctgacct gcctggtcaa   9780

aggcttctat cccagcgaca tcgccgtgga gtgggagagc aatgggcagc cggagaacaa   9840

ctacaagacc acgcctcccg tgctggactc cgacggctcc ttcttcctct acagcaagct   9900

caccgtggac aagagcaggt ggcagcaggg gaacgtcttc tcatgctccg tgatgcatga   9960

ggctctgcac aaccactaca cgcagaagag cctctccctg tctccgggta aatgaggaat  10020

t                                                                  10021


<210>  21
<211>  7350
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  pSIN-1.8-OM-IFNa-2B Vector

<400>  21
tcgagatcaa ttgctagact aggatccccc gtgctgcaga accgagcggc tattgacttc     60

ttgctcctag ctcacggcca tggctgtgag gacattgcgg gaatgtgttg tttcaatctg    120

agtgatcaca gtgagtctat acagaagaag ttccagctaa tgaaggaaca tgtcaataag    180

atcggcgtga acaacgaccc aatcggaagt tggctgcgag gattattcgg aggaatagga    240

gaatgggccg tacacttgct gaaaggactg cttttggggc ttgtagttat cttgttgcta    300

gtagtatgct tgccttgcct tttgcaatgt gtatctagta gtattcgaaa gatgattgat    360

aattcactcg gctatcgcga ggaatataaa aaaattacag gaggcttata agcagcccga    420

aagaagagcg taggcgagtt cttgtattcc gtgtgatagc tggttggatt ggtaattgat    480

cggctggcac gcggaatata ggaggtcgct gaatagtaaa cttgtagact tggctacagc    540

atagagtatc ttctgtagct ctgatgactg ctaggaaata atgctacgga taatgtgggg    600

agggcaaggc ttgcgaatcg ggttgtaacg ggcaaggctt gactgagggg acaatagcat    660

gtttaggcga aaagcggggc ttcggttgta cgcggttagg agtcccctca ggatatagta    720

gtttcgcttt tgcataggga gggggacgga ttggacgaac cactgaattc cgcattgcag    780

agatattgta tttaagtgcc tagctcgata caataaacgc catttgacca ttcaccacat    840

tggtgtgcac ctgggttgat ggccggaccg ttgattccct grcgactacg agcacatgca    900

tgaagcagaa ggcttcattt ggtgaccccg acgtgatcgt tagggaatac gcgctcactg    960

gccgtcgttt tacaacgtcg tgactgggaa aaccctggcg ttacccaact taatcgcctt   1020

gcagcacatc cccctttcgc cagctggcgt aatagcgaag aggcccgcac cgatcgccct   1080

tcccaacagt tgcgcagcct gaatggcgaa tggaaattgt aagcgttaat attttgttaa   1140

aattcgcgtt aaatttttgt taaatcagct cattttttaa ccaataggcc gaaatcggca   1200

aaatccctta taaatcaaaa gaatagaccg agatagggtt gagtgttgtt ccagtttgga   1260

acaagagtcc actattaaag aacgtggact ccaacgtcaa agggcgaaaa accgtctatc   1320

agggcgatgg cccactacgt gaaccatcac cctaatcaag ttttttgggg tcgaggtgcc   1380

gtaaagcact aaatcggaac cctaaaggga gcccccgatt tagagcttga cggggaaagc   1440

cggcgaacgt ggcgagaaag gaagggaaga aagcgaaagg agcgggcgct agggcgctgg   1500

caagtgtagc ggtcacgctg cgcgtaacca ccacacccgc cgcgcttaat gcgccgctac   1560

agggcgcgtc aggtggcact tttcggggaa atgtgcgcgg aacccctatt tgtttatttt   1620

tctaaataca ttcaaatatg tatccgctca tgagacaata accctgataa atgcttcaat   1680

aatattgaaa aaggaagagt atgagtattc aacatttccg tgtcgccctt attccctttt   1740

ttgcggcatt ttgccttcct gtttttgctc acccagaaac gctggtgaaa gtaaaagatg   1800

ctgaagatca gttgggtgca cgagtgggtt acatcgaact ggatctcaac agcggtaaga   1860

tccttgagag ttttcgcccc gaagaacgtt ttccaatgat gagcactttt aaagttctgc   1920

tatgtggcgc ggtattatcc cgtattgacg ccgggcaaga gcaactcggt cgccgcatac   1980

actattctca gaatgacttg gttgagtact caccagtcac agaaaagcat cttacggatg   2040

gcatgacagt aagagaatta tgcagtgctg ccataaccat gagtgataac actgcggcca   2100

acttacttct gacaacgatc ggaggaccga aggagctaac cgcttttttg cacaacatgg   2160

gggatcatgt aactcgcctt gatcgttggg aaccggagct gaatgaagcc ataccaaacg   2220

acgagcgtga caccacgatg cctgtagcaa tggcaacaac gttgcgcaaa ctattaactg   2280

gcgaactact tactctagct tcccggcaac aattaataga ctggatggag gcggataaag   2340

ttgcaggacc acttctgcgc tcggcccttc cggctggctg gtttattgct gataaatctg   2400

gagccggtga gcgtgggtct cgcggtatca ttgcagcact ggggccagat ggtaagccct   2460

cccgtatcgt agttatctac acgacgggga gtcaggcaac tatggatgaa cgaaatagac   2520

agatcgctga gataggtgcc tcactgatta agcattggta actgtcagac caagtttact   2580

catatatact ttagattgat ttaaaacttc atttttaatt taaaaggatc taggtgaaga   2640

tcctttttga taatctcatg accaaaatcc cttaacgtga gttttcgttc cactgagcgt   2700

cagaccccgt agaaaagatc aaaggatctt cttgagatcc tttttttctg cgcgtaatct   2760

gctgcttgca aacaaaaaaa ccaccgctac cagcggtggt ttgtttgccg gatcaagagc   2820

taccaactct ttttccgaag gtaactggct tcagcagagc gcagatacca aatactgtcc   2880

ttctagtgta gccgtagtta ggccaccact tcaagaactc tgtagcaccg cctacatacc   2940

tcgctctgct aatcctgtta ccagtggctg ctgccagtgg cgataagtcg tgtcttaccg   3000

ggttggactc aagacgatag ttaccggata aggcgcagcg gtcgggctga acggggggtt   3060

cgtgcacaca gcccagcttg gagcgaacga cctacaccga actgagatac ctacagcgtg   3120

agctatgaga aagcgccacg cttcccgaag ggagaaaggc ggacaggtat ccggtaagcg   3180

gcagggtcgg aacaggagag cgcacgaggg agcttccagg gggaaacgcc tggtatcttt   3240

atagtcctgt cgggtttcgc cacctctgac ttgagcgtcg atttttgtga tgctcgtcag   3300

gggggcggag cctatggaaa aacgccagca acgcggcctt tttacggttc ctggcctttt   3360

gctggccttt tgctcacatg ttctttcctg cgttatcccc tgattctgtg gataaccgta   3420

ttaccgcctt tgagtgagct gataccgctc gccgcagccg aacgaccgag cgcagcgagt   3480

cagtgagcga ggaagcggaa gagcgcccaa tacgcaaacc gcctctcccc gcgcgttggc   3540

cgattcatta atgcagctgg cacgacaggt ttcccgactg gaaagcgggc agtgagcgca   3600

acgcaattaa tgtgagttag ctcactcatt aggcacccca ggctttacac tttatgcttc   3660

cggctcgtat gttgtgtgga attgtgagcg gataacaatt tcacacagga aacagctatg   3720

accatgatta cgccaagcgc gcattggtaa ttgatcggct ggcacgcgga atataggagg   3780

tcgctgaata gtaaacttgt agacttggct acagcataga gtatcttctg tagctctgat   3840

gactgctagg aaataatgct acggataatg tggggagggc aaggcttgcg aatcgggttg   3900

taacgggcaa ggcttgactg aggggacaat agcatgttta ggcgaaaagc ggggcttcgg   3960

ttgtacgcgg ttaggagtcc cctcaggata tagtagtttc gcttttgcat agggaggggg   4020

aaatgtagtc ttatgcaata ctcttgtagt cttgcaacat gcttatgtaa cgatgagtta   4080

gcaacatgcc ttataaggag agaaaaagca ccgtgcatgc cgattggtgg gagtaaggtg   4140

gtatgatcgt ggtatgatcg tgccttgtta ggaaggcaac agacgggtct aacacggatt   4200

ggacgaacca ctgaattccg cattgcagag atattgtatt taagtgccta gctcgataca   4260

ataaacgcca tttgaccatt caccacattg gtgtgcacct gggttgatgg ccggaccgtt   4320

gattccctgr cgactacgag cacatgcatg aagcagaagg cttcatttgg tgaccccgac   4380

gtgatcgtta gggaatagtg gtcggccaca ggcggcgtgg cgatcctgtc ctcatccgtc   4440

tcgcttattc ggggagcgga cgatgaccct agtagagggg gctgcggctt aggagggcag   4500

aagctgagtg gcgtcggagg gagccctact gcagggggcc aacataccct accgagaact   4560

cagagagtcg ttggaagacg ggaaggaagc ccgacgactg agcggtccac cccaggcgtg   4620

attccggttg ctctgcgtga ttccggtcgc ccggtggatc aagcatggaa gccgtcataa   4680

aggtgatttc gtccgcgtgt aagacctatt gcgggaaaac ctctccttct aagaaggaaa   4740

taggggctat gttgtccctg ttacaaaagg aagggttgct tacgtccccc tcagacttat   4800

attccccggg gtcctgggat cccattaccg cggcgctctc tcagcgggct atggtacttg   4860

gaaaatcggg agagttaaaa acctggggat tggttttggg ggcattgaag gcggctcgac   4920

ggatccgtta accctagaac tagtggatct ctgcccttgt gctgactcct gcacacaaga   4980

gcatttccct gtagccaaac agcgattagc cataagctgc acctgacttt gaggattaag   5040

agtttgcaat taagtggatt gcagcaggag atcagtggca gggttgcaga tgaaatcctt   5100

ttctaggggt agctaagggc tgagcaacct gtcctacagc acaagccaaa ccagccaagg   5160

gttttcctgt gctgttcaca gaggcagggc cagctggagc tggaggaggt tgtgctggga   5220

cccttctccc tgtgctgaga atggagtgat ttctgggtgc tgttcctgtg gcttgcactg   5280

agcagctcaa gggagatcgg tgctcctcat gcagtgccaa aactcgtgtt tgatgcagaa   5340

agatggatgt gcacctccct cctgctaatg cagccgtgag cttatgaagg caatgagccc   5400

tcagtgcagc aggagctgta gtgcactcct gtaggtgcta gggaaaatct ctggttccca   5460

gggatgcatt cataagggca atatatcttg aggctgcgcc aaatctttct gaaatattca   5520

tgcgtgttcc cttaatttat agaaacaaac acagcagaat aattattcca atgcctcccc   5580

tcgaaggaaa cccatatttc catgtagaaa tgtaacctat atacacacag ccatgctgca   5640

tccttcagaa cgtgccagtg ctcatctccc atggcaaaat actacaggta ttctcactat   5700

gttggacctg tgaaaggaac catggtaaga aacttcggtt aaaggtatgg ctgcaaaact   5760

actcatacca aaacagcaga gctccagacc tcctcttagg aaagagccac ttggagaggg   5820

atggtgtgaa ggctggaggt gagagacaga gcctgtccca gttttcctgt ctctattttc   5880

tgaaacgttt gcaggaggaa aggacaactg tactttcagg catagctggt gccctcacgt   5940

aaataagttc cccgaacttc tgtgtcattt gttcttaaga tgctttggca gaacactttg   6000

agtcaattcg cttaactgtg actaggtctg taaataagtg ctccctgctg ataaggttca   6060

agtgacattt ttagtggtat ttgacagcat ttaccttgct ttcaagtctt ctaccaagct   6120

cttctatact taagcagtga aaccgccaag aaacccttcc ttttatcaag ctagtgctaa   6180

ataccattaa cttcataggt tagatacggt gctgccagct tcacctggca gtggttggtc   6240

agttctgctg gtgacaaagc ctccctggcc tgtgctttta cctagaggtg aatatccaag   6300

aatgcagaac tgcatggaaa gcagagctgc aggcacgatg gtgctgagcc ttagctgctt   6360

cctgctggga gatgtggatg cagagacgaa tgaaggacct gtcccttact cccctcagca   6420

ttctgtgcta tttagggttc taccagagtc cttaagaggt tttttttttt tttggtccaa   6480

aagtctgttt gtttggtttt gaccactgag agcatgtgac acttgtctca agctattaac   6540

caagtgtcca gccaaaatca attgcctggg agacgcagac cattacctgg aggtcaggac   6600

ctcaataaat attaccagcc tcattgtgcc gctgacagat tcagctggct gctccgtgtt   6660

ccagtccaac agttcggacg ccacgtttgt atatatttgc aggcagcctc ggggggacca   6720

tctcaggagc agagcaccgg cagccgcctg cagagccggg cagtacctca ccatggcttt   6780

gacctttgcc ttactggtgg ctctcctggt gctgagctgc aagagcagct gctctgtggg   6840

ctgcgatctg cctcagaccc acagcctggg cagcaggagg accctgatgc tgctggctca   6900

gatgaggaga atcagcctgt ttagctgcct gaaggatagg cacgattttg gctttcctca   6960

agaggagttt ggcaaccagt ttcagaaggc tgagaccatc cctgtgctgc acgagatgat   7020

ccagcagatc tttaacctgt ttagcaccaa ggatagcagc gctgcttggg atgagaccct   7080

gctggataag ttttacaccg agctgtacca gcagctgaac gatctggagg cttgcgtgat   7140

ccagggcgtg ggcgtgaccg agacccctct gatgaaggag gatagcatcc tggctgtgag   7200

gaagtacttt cagaggatca ccctgtacct gaaggagaag aagtacagcc cctgcgcttg   7260

ggaagtcgtg agggctgaga tcatgaggag ctttagcctg agcaccaacc tgcaagagag   7320

cttgaggtct aaggagtaaa aagtctaggc                                    7350


<210>  22
<211>  16051
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  16 kbp Ovalbumin Sequence

<400>  22
ctgcagccca ggcagcacac tagagcagag aaatctagtt agcagcaacc actggcagac     60

agaaatgatt atatagatta catactgacc ctagcctctt acactgccta ctgcatcact    120

gaaaggactg ggaagaagag agtgcaataa cgaagctgaa gctaggagga aggcaaggag    180

aactgaagct gactagggaa aagggggatt aaaggtttaa gtgtctattc catagtttgc    240

tggtttgttt tttgtcaatt cctgaatcag taatttttat gttaattagc aaaaaattac    300

aaacactccc caagtcagga ctgttaccta caacagaagc tcagatcagc tgagccttag    360

tcttttggtc cctccctagg gaatgctgta tgtgtctctc tctccaggcc tgctcaaaat    420

tgacctcaga cccaaacttt tgctgaatct ccagtaccac ctcttttgct cctaactaga    480

taacaaagcc ctgagcgctt tgcttttagc aaagctttaa gtgccattac caactgcacc    540

tggagccttt acctacccct atggacccag gctctatatt taagctctgc cctgaacctt    600

cacttctttc ctgtcctaag ttagatgtac tagtatggtg tgtactatgt ctccagttca    660

aacacagctg tgcccatacc tggccaagga ctcctagtat gacctgggct gtgccttgct    720

gctaaggacc tgctgggtga ttgctggacc tgatcctaat cctgaattaa gaaatgattt    780

cttggcttga ctggatgtgc cctgtggtat gatactgcct tatgatttgg actcttgttt    840

gcagctgtgc aaatccctaa ggagcccagt ctctggccac ctggaatctt gtcactacca    900

aacttcctga gggactggtc ttgctctggg ttctgatctc tggacagtac tcacccttta    960

ctcagcccag gctcccagtt aagccccttt ccaccctgcc aggctctccg ctccatccct   1020

agcaggggct ctcatgacag tgtgaccccc ccttactcag gtcagggcca cttgtgccac   1080

gttcctttcc tgtcttctgt ccctgccttg gctctaaagc agtgtgctac catccacaac   1140

cactgcatct ctctaaagta agcctctcct gagcccaagt ctctgtaacg aggaaggatg   1200

cactttgctc agaaggatgc gaggctgctt ctgagctctg agggcactga cctcccatga   1260

ggtacacccc atacccagga ccacaattca gcctgctgga accatcaact cctgctggag   1320

taaggccata gcaagaccag catccacctc cctgcagccc tgccctgccc agatattggg   1380

cctgctgatc tcaggatgca gacttgcttc tcagcttgac ctaagcattg ccctgtcttt   1440

atggacccac ctggttagca agttcagtgc agaaggaggc tgttggcatc tagctaattt   1500

tccacccaca ttactgtctg ctgactcatt ctacgtctct cccatcttgt tacaataata   1560

atttgggaga tcatattgaa ggtcttaata aagtcaaggc atgtgatatt ctctgctttg   1620

cctttgtttc tagaataagc cacttcatca tagaagatga aaatgctgat cagcagagat   1680

ctgtgcttga taaatccatg ctggcttttc ctatcacctt atattccttc atatgccttg   1740

agacacccaa ggaggccttg gatcagagct gtctgtagca gtcctaactg gtatacaatt   1800

agttgtacaa caggtagtga tccgcataat agttggcgtg agaaagtggg cctgtgctgt   1860

gtcaagcata gagtttgggt tccagtcctg ttctgcatgg cacatatgcc tgagcagctg   1920

ggtaatctct gcattccaat tggaaggcag gggcctgtag gcagttccca cttggcatgg   1980

gtgattgtac cacctgtgtc ctcatctgtg aagcatcatg ttttcattca aatatccttt   2040

tgtttgacag tagaaatgaa cagaattgtt tttttttcct aagcaaattc tgcaagagct   2100

ctgaagaaca aggtgtcagt gaacttctag ctccatagat aggacttgca tcacatgtca   2160

tgccttgatt ggaggtctat ccgatactga acaacttgtg gttccctgag ggaatgtaag   2220

attactgata ctactctctc tttatgttag ctacaataaa tggtaggtta agcaatagat   2280

acagagtttg agtgcctttc ttacaagcat catagtgaac aaatccactg gtgatctacc   2340

ttttcaataa ctacagagaa ttgtaatctc ttggattctc ctccttcccc gttctgaaaa   2400

tgtgttcttt ttttccaaat cagaaacctt cctcaaccac cctgactatt ctttggacat   2460

tgttttgttc ttgctcctaa ataggcttta taatttttgt aagtgaaagg ctttgcatgc   2520

aggtgaggct acaactcatt cagtaacaat gaggaagact gtcagatttt ggggaaaatt   2580

ctcccaccca accttttgct agccagtaag atgtaatcac tgaatgtcat gccacaaaga   2640

ccataccaac atcagaccac atatctacag gaagctttaa ggaatcattg actgtacagt   2700

gaagggtaaa tcaaattaaa atgaatgtga ggtctgatac gagatatcct catgggaatc   2760

aagagcaaag acaaatagtt tttcacagtc ttgtcatgat ctgtcacaga ccaaggcagc   2820

acagcaggca acaatgttgg tctcttcaga atggcacagc accgctgcag aaaaatgcca   2880

ggtggactat gaactcacat ccaaaggagc ttgacctgat acctgatttt cttcaaacag   2940

gggaaacaac acaatcccac aaaatagctc agagagaaac catcactgat ggctacagca   3000

ccaaggtatg caatggcaat ccattcgaca ttcatctgtg acctgagcaa aatgatttat   3060

ctctccatga atggttgctt ctttccctca tgaaaaggca atttccacac tcacaatatg   3120

caacaaagac aaacagagaa caattaatgt gctccttcct aatgtcaaaa ttgtagtggc   3180

aaagaggaga acaaaatctc aagttctgag taggttttag tgattggata agaggctttg   3240

acctgtgagc tcacctggac ttcatatcct tttggataaa aagtgctttt ataactttca   3300

ggtctccgag tctttattca tgagactgtt ggtttaggga cagacccaca atgaaatgcc   3360

tggcatagga aagggcagca gagccttagc tgaccttttc ttgggacaag cattgtcaaa   3420

caatgtgtga caaaactatt tgtactgctt tgcacagctg tgctgggcag ggcaatccat   3480

tgccacctat cccaggtaac cttccaactg caagaagatt gttgcttact ctctctagac   3540

ccccaagtca aaccaactat gcaggtatgc tgacaacgct atgatgacag cctgttctga   3600

tcaagatctc atttgttcat ggacaatttt tgttgcttgc agctggtctt ccattgggaa   3660

agagtgtagt atatccttct catctgacag aaaagcagaa attctcatgc tccacactta   3720

atctacattg ttttaaacca ccagctactt cttggagagg aaaaatggct tttataagac   3780

tcacaaaaca aagctctgca agtcaaatgc atacaaaact gttctgtagg tctggaatca   3840

ggacactatg tggaagtcaa atagagaagc tttaaaaaaa cctttgggat cattctcatc   3900

ttatatttgc agcacgatac tatgacagtg ataactgaca taactgcatc aatttccttg   3960

atattttatt tgtcttaaag tacaagacat agagatggac gtaaagatgg acatatgact   4020

caggtctgga caggtccgtg gtccatgtat gataaaagag atgaagggaa ggagaatgga   4080

gactgtctaa gaagggcttc agggacgttc tgaaggcaga tttgactgaa tcagatgtac   4140

tgtccaagtc tcatatgtag caatggaaga ctgatattgg agaaatataa agaaatggct   4200

gtgaactcaa agtgaccctg aacagaaaag ggatatggag ttaaaataat ggcacagaac   4260

tgaggtttat atgatatacc atgggctgca gagggtcaga gtgctccacc atgggcctct   4320

cttgggctgc agggaacttc tgttctacac ctggaacacc tcctgccctc ctccgcactg   4380

acctcagtgt catcagggct gtttctctca cattttctca ctcacctctc ccaactacca   4440

ttgtacagca gttgttctta catcttgctc ctcctgaggt gcatctagca tcgatcactg   4500

gctcagctct ggccagtggc agctcccttt tgaggacacg ggacagctgc tgggctctgt   4560

tcacagaggc cactccagca gacctccact accacaactt gtagtgtaaa tccactacaa   4620

ctttctgagc tacagaaatg aaatggagac cctctctgct atgggataca aaagaggaaa   4680

cgtggcgttt agtgctctgg ctcactggta cacccaacca cagggtgaga agcagcctgt   4740

tgttattcac tactcttagg acagattatg gtgaattgtt aataaaagca tttcttcata   4800

acatccaaag gaggaaatac actaaattat attttttatt tattaattac acatgcttaa   4860

ttatatatgg catggttgct ttgaaagaac cttgtcctta ctgaccagat ctgctgtttg   4920

ctgagacaaa atggctgaca attttggcca tggtggatac cttccccctt ttctgtagca   4980

ttaggacaga agttattctg gagcctgtct gacaagtcag acttgataac tttaagtatt   5040

tggaagtgtg cttttcatgc tggatgtcat ctccagaacc tccctgtctg gtaagcagtt   5100

ccctgcctta gtaagagccg aaacggtctc tcttttcctt gttatctcac caggatatta   5160

caatgtgaca ggactatctg aactacgcca acctgcaaat tccaaatata tatatatata   5220

tgtaagatat ctatacacaa attattagtg tttgattgac accagatgac agagaagtgc   5280

atctgagaaa acctattccc aatctccttt ctctttctgc agactgacat gcatttcata   5340

ggtagagata acatttactg ggaagcacat ctatcatcat aaaaagcagg caagattttc   5400

agactttctt agtggctgaa atagaagcaa aagacgtgat taaaaacaaa atgaaacaaa   5460

aaaaatcagt tgatacctgt ggtgtagaca tccagcaaaa aaatattatt tgcactacca   5520

tcttgtctta agtcctcaga cttggcaagg agaatgtaga tttctacagt atatatgttt   5580

tcacaaaagg aaggagagaa acaaaagaaa atggcactga ctaaacttca gctagtggta   5640

taggaaagta attctgctta acagagattg cagtgatctc tatgtatgtc ctgaagaatt   5700

atgttgtact tttttccccc atttttaaat caaacagtgc tttacagagg tcagaatggt   5760

ttctttactg tttgtcaatt ctattatttc aatacagaac aatagcttct ataactgaaa   5820

tatatttgct attgtatatt atgattgtcc ctcgaaccat gaacactcct ccagctgaat   5880

ttcacaattc ctctgtcatc tgccaggcca ttaagttatt catggaagat ctttgaggaa   5940

cactgcaagt tcatatcata aacacatttg aaattgagta ttgttttgca ttgtatggag   6000

ctatgttttg ctgtatcctc agaaaaaaag tttgttataa agcattcaca cccataaaaa   6060

gatagattta aatattccag ctataggaaa gaaagtgcgt ctgctcttca ctctagtctc   6120

agttggctcc ttcacatgca tgcttcttta tttctcctat tttgtcaaga aaataatagg   6180

tcacgtcttg ttctcactta tgtcctgcct agcatggctc agatgcacgt tgtagataca   6240

agaaggatca aatgaaacag acttctggtc tgttactaca accatagtaa taagcacact   6300

aactaataat tgctaattat gttttccatc tctaaggttc ccacattttt ctgttttctt   6360

aaagatccca ttatctggtt gtaactgaag ctcaatggaa catgagcaat atttcccagt   6420

cttctctccc atccaacagt cctgatggat tagcagaaca ggcagaaaac acattgttac   6480

ccagaattaa aaactaatat ttgctctcca ttcaatccaa aatggaccta ttgaaactaa   6540

aatctaaccc aatcccatta aatgatttct atggcgtcaa aggtcaaact tctgaaggga   6600

acctgtgggt gggtcacaat tcaggctata tattccccag ggctcagcca gtgtctgtac   6660

atacagctag aaagctgtat tgcctttagc agtcaagctc gaaaggtaag caactctctg   6720

gaattacctt ctctctatat tagctcttac ttgcacctaa actttaaaaa attaacaatt   6780

attgtgctat gtgttgtatc tttaagggtg aagtacctgc gtgatacccc ctataaaaac   6840

ttctcacctg tgtatgcatt ctgcactatt ttattatgtg taaaagcttt gtgtttgttt   6900

tcaggaggct tattctttgt gcttaaaata tgtttttaat ttcagaacat cttatcctgt   6960

cgttcactat ctgatatgct ttgcagtttg cttgattaac ttctagccct acagagtgca   7020

cagagagcaa aatcatggtg ttcagtgaat tctggggagt tattttaatg tgaaaattct   7080

ctagaagttt aattcctgca aagtgcagct gctgatcact acacaagata aaaatgtggg   7140

gggtgcataa acgtatattc ttacaataat agatacatgt gaacttatat acagaaaaga   7200

aaatgagaaa aatgtgtgtg tgtatactca cacacgtggt cagtaaaaac ttttgagggg   7260

tttaatacag aaaatccaat cctgaggccc cagcactcag tacgcatata aagggctggg   7320

ctctgaagga cttctgactt tcacagatta tataaatctc aggaaagcaa ctagattcat   7380

gctggctcca aaagctgtgc tttatataag cacactggct atacaatagt tgtacagttc   7440

agctctttat aatagaaaca gacagaacaa gtataaatct tctattggtc tatgtcatga   7500

acaagaattc attcagtggc tctgttttat agtaaacatt gctattttat catgtctgca   7560

tttctcttct gtctgaatgt caccactaaa atttaactcc acagaaagtt tatactacag   7620

tacacatgca tatctttgag caaagcaaac catacctgaa agtgcaatag agcagaatat   7680

gaattacatg cgtgtctttc tcctagacta catgacccca tataaattac attacttatc   7740

tattctgcca tcaccaaaac aaaggtaaaa atacttttga agatctactc atagcaagta   7800

gtgtgcaaca aacagatatt tctctacatt tatttttagg gaataaaaat aagaaataaa   7860

atagtcagca agcctctgct ttctcatata tctgtccaaa cctaaagttt actgaaattt   7920

gctctttgaa tttccagttt tgcaagccta tcagattgtg ttttaatcag aggtactgaa   7980

aagtatcaat gaattctagc tttcactgaa caaaaatatg tagaggcaac tggcttctgg   8040

gacagtttgc tacccaaaag acaactgaat gcaaatacat aaatagattt atgaatatgg   8100

ttttgaacat gcacatgaga ggtggatata gcaacagaca cattaccaca gaattacttt   8160

aaaactactt gttaacattt aattgcctaa aaactgctcg taatttactg ttgtagccta   8220

ccatagagta ccctgcatgg tactatgtac agcattccat ccttacattt tcactgttct   8280

gctgtttgct ctagacaact cagagttcac catgggctcc atcggtgcag caagcatgga   8340

attttgtttt gatgtattca aggagctcaa agtccaccat gccaatgaga acatcttcta   8400

ctgccccatt gccatcatgt cagctctagc catggtatac ctgggtgcaa aagacagcac   8460

caggacacaa ataaataagg tgagcctaca gttaaagatt aaaacctttg ccctgctcaa   8520

tggagccaca gcacttaatt gtatgataat gtcccttgga aactgcatag ctcagaggct   8580

gaaaatctga aaccagagtt atctaaaagt gtggccacct ccaactccca gagtgttacc   8640

caaatgcact agctagaaat cttgaaactg gattgcataa cttctttttg tcataaccat   8700

tatttcagct actattattt tcaattacag gttgttcgct ttgataaact tccaggattc   8760

ggagacagta ttgaagctca ggtacagaaa taatttcacc tccttctcta tgtccctttc   8820

ctctggaagc aaaatacagc agatgaagca atctcttagc tgttccaagc cctctctgat   8880

gagcagctag tgctctgcat ccagcagttg ggagaacact gttcataaga acagagaaaa   8940

agaaggaagt aacaggggat tcagaacaaa cagaagataa aactcaggac aaaaataccg   9000

tgtgaatgag gaaacttgtg gatatttgta cgcttaagca agacagctag atgattctgg   9060

ataaatgggt ctggttggaa aagaaggaaa gcctggctga tctgctggag ctagattatt   9120

gcagcaggta ggcaggagtt ccctagagaa aagtatgagg gaattacaga agaaaaacag   9180

cacaaaattg taaatattgg aaaaggacca catcagtgta gttactagca gtaagacaga   9240

caggatgaaa aatagttttg taaacagaag tatctaacta ctttactctg ttcatacact   9300

acgtaaaact tactaagtaa taaaactaga ataacaacat ctttctttct ctttgtattc   9360

agtgtggcac atctgtaaac gttcactctt cacttagaga catcctcaac caaatcacca   9420

aaccaaatga tgtttattcg ttcagccttg ccagtagact ttatgctgaa gagagatacc   9480

caatcctgcc agtaagttgc tctaaaatct gatctgagtg tattccatgc caaagctcta   9540

ccattctgta atgcaaaaac agtcagagtt ccacatgttt cactaagaaa atttcttttt   9600

ctcttgtttt tacaaatgaa agagaggaca aataacattt ctctatcacc gacctgaaac   9660

tctacagtct tcagagaatg aatggcttgc taaaagaatg tcaaatctta ctatacagct   9720

atttcatatt acactactaa atacactata aggcatagca tgtagtaata cagtgtaaaa   9780

tagcttttta cactactata ttattaatat ctgttaattc cagtcttgca tttcacattt   9840

gcaaaacgtt ttgaaattcg tatctgaaag ctgaatactc ttgctttaca ggaatacttg   9900

cagtgtgtga aggaactgta tagaggaggc ttggaaccta tcaactttca aacagctgca   9960

gatcaagcca gagagctcat caattcctgg gtagaaagtc agacaaatgg taaggtagaa  10020

catgctttgt acatagtgag agttggttca ccctaatact gagaacttgg atatagctca  10080

gccagcgtgc tttgcgttca agcttaccag agctgttgta tgcctgttaa gcagggcata  10140

cagtcatgag gctcttgaaa aatcttaaca gacaaagggc aatggaaaat cggagttaag  10200

ggatggtagg gataaaatgc atagaaagag gtaccacaat tttgattttt gccctaatgc  10260

ctctctgcgt ggttcctcaa tttttctact tcattcctca tctcctcaga gcattccttt  10320

ccctcatgct tgaaacacag atgaaagact gtgaattcta actgagatga aaacatccac  10380

aaccacacaa cctctggtgt ggagtcacat tctgtgaagg caaaaactag gccacgtaat  10440

ctatgcgtgc aagctacgcg taagctatgt gtgtgacagg acaatgtgag gaacatacta  10500

tgtgcacaag gactgcagaa taaacaggag caaagttttt gaagaaaaca gagtaaaatc  10560

ctgttttcct cttttgttac attctttaca tatatctcaa atttcctctt tggttagaag  10620

caagtaatat ttatgtttct tggtactgtt tgggttgaag accattctgg gataagagaa  10680

attccagtgg ttcttcccct aatcataaaa tgtcaggttt agtttttttg taacacagaa  10740

atctcttcat cttttatctt ttgttgtgat tcttgataga gagagaaaca agacttactg  10800

acaatagcag caagaaaatc aatcttggaa gaacaagatt gcaattgcaa aaacaaacca  10860

atgtccttgc ccctacatcc tcttccccat aaattctaca ttctctatct accttgtgct  10920

tgccaacatg atatacgtaa actctctttt cctattcatt cttaaaggaa ttatcagaaa  10980

tgtccttcag ccaagctccg tggattctca aactgcaatg gttctggtta atgccattgt  11040

cttcaaagga ctgtgggaga aagcatttaa ggatgaagac acacaagcaa tgcctttcag  11100

agtgactgag gtatatgggc ataccttaga gatgtaatct agaatttatg aagagagtag  11160

acatgttgtt atatgaacac tgcattagcg tatctgctca tttgtctgca tctctttcag  11220

acactgtgtt aaaagcaggg aattttcctt atgtctctct cgtcacaata ttcctgacat  11280

tgcaaagctc ctgagaaata acttcagatt ccacttttcc taggaaggct tctggatgag  11340

aactaatcat cttaactgta actagacatt tctgcatcca agaataatct ttgttaaaac  11400

tatattctct ctctcttttt tttttttttt tggttctcca gcaagaaagc aaacctgtgc  11460

agatgatgta ccagattggt ttatttagag tggcatcaat ggcttctgag aaaatgaaga  11520

tcctggagct tccatttgcc agtgggacaa tgagcatgtt ggtgctgttg cctgatgaag  11580

tctcaggcct tgagcaggta tggccctaga agttggcttc agaatattaa aaacacatgg  11640

aaatttagct gttgtaaagc tcttttcaac acagttatcc taaaacattt aaccagcaca  11700

aatttcatca tgattcaata tgtgattgtt gcatagaagt gtagatttgt cccactgggt  11760

cctgcaatag cccatgctga gcatggcttg ctgaaagaac tgctttagag ggtgaaaagt  11820

ttgacacagc agacaagatg attctcacct aagcagctgt tactgtagtg gcttgaactc  11880

taaaggtctt gtatctccat tcctgtgcac tgaggagctt cttggaaagt tcatataagg  11940

tttactagtt ctaactatta tctcatttgg tggcactcaa tgtgctttgt tcacgtcttc  12000

ataaattaat ctatctaaaa attggatgtg gttaaagcaa tttcagaaat aacatgtaca  12060

taatgtacaa ttattgatat gaacagaaca caggcatagc atattgtaat taggaggact  12120

gtagttattt tgaataggaa acacaatgta ataaatgaga attcattgaa atgttagtat  12180

gctaactcaa tctaaattat aaagataaag aggcatttaa tcacagctag atttccatca  12240

cttgtgacag acaggcatat gaatgattat gtacagctct aggaaaaaaa gtatgtagga  12300

aaactagtac attttgatta gaaagtctga aaatgaggtg ccttgatcaa agagaatacg  12360

tgtgtttgag aaaaaaaaag tttggataga ggtggtaaga gagaatatat tgaaatggtg  12420

tttctacaaa ctgccatggc cagatttgtg taagagacat tcagtaagta ggcaaggaaa  12480

gaaatattac taggtacaaa gcaacatcag taataccaaa agaaaccaat tattccagat  12540

gccaatctcg taatagggtt aagagatttc cacccctcta gtggtcacca gtgcaaccag  12600

taactttgct aatttacatt ttcttttttt aaatggcaga tatagctttg aactgagtga  12660

tcatgaactg gtactgtgta atagatgaag acatacttga cgactaaact tctgattttt  12720

aaaaactcaa attctcttga aagatcagtt cccagtctag taacagctga tagtttaagt  12780

atcagtaatt ggctaccatt aacaactggc tcctgagagg tcttaaatgt agagacagct  12840

ttaaactcaa aagcacagag tgatttttag aatagatttc ccaagcaaag aaaataaaca  12900

gggaggagct ttaagggagt agccatctca ttattattat tatttaaaga aatggcagca  12960

agcctacaaa agaaaaataa gacagagcag agaagaaaga gtcatggtat gcttttctat  13020

cttagcaaaa ttaatctcta catgcctagg aaaaagccat gacaagagca atcagttcaa  13080

aaggtgtatg caaaaaacca cataatagta actagtactg cattgccagg aaggaagtta  13140

tgtcgccatt ccatggatct cattctcatt tccttgcagc ttgagagtat aatcaacttt  13200

gaaaaactga ctgaatggac cagttctaat gttatggaag agaggaagat caaagtgtac  13260

ttacctcgca tgaagatgga ggaaaaatac aacctcacat ctgtcttaat ggctatgggc  13320

attactgacg tgtttagctc ttcagccaat ctgtctggca tctcctcagc agagagcctg  13380

aagatatctc aagctgtcca tgcagcacat gcagaaatca atgaagcagg cagagaggtg  13440

gtagggtcag cagaggctgg agtggatgct gcaagcgtct ctgaagaatt tagggctgac  13500

catccattcc tcttctgtat caagcacatc gcaaccaacg ccgttctctt ctttggcaga  13560

tgtgtttccc cttaaaaaga agaaagctga aaaactctgt cccttccaac aagacccaga  13620

gcactgtagt atcaggggta aaatgaaaag tatgttatct gctgcatcca gacttcataa  13680

aagctggagc ttaatctaga aaaaaaatca gaaagaaatt acactgtgag aacaggtgca  13740

attcactttt cctttacaca gagtaatact ggtaactcat ggatgaaggc ttaagggaat  13800

gaaattggac tcacagtact gagtcatcac actgaaaaat gcaacctgat acatcagcag  13860

aaggtttatg ggggaaaaat gcagccttcc aattaagcca gatatctgta tgaccaagct  13920

gctccagaat tagtcactca aaatctctca gattaaatta tcaactgtca ccaaccattc  13980

ctatgctgac aaggcaattg cttgttctct gtgttcctga tactacaagg ctcttcctga  14040

cttcctaaag atgcattata aaaatcttat aattcacatt tctccctaaa ctttgactca  14100

atcatggtat gttggcaaat atggtatatt actattcaaa ttgttttcct tgtacccata  14160

tgtaatgggt cttgtgaatg tgctcttttg ttcctttaat cataataaaa acatgtttaa  14220

gcaaacactt ttcacttgta gtatttgaag tacagcaagg ttgtgtagca gggaaagaat  14280

gacatgcaga ggaataagta tggacacaca ggctagcagc gactgtagaa caagtactag  14340

tgggtgagaa gttgaacaag agtcccctac aagcaactta atctaataag ctagtggtct  14400

acatcagcta aaagagcata gtgagggatg aaattggttc tcctttctaa gcatcacctg  14460

ggacaactca tctggagcag tgtgtccaat ctgccgctgc cctgatctcg gctggggtga  14520

tgggacagac cttggctgcc actgagacat ctgagacact gagatctgtc tcaactcaga  14580

tttacccaag aacagctcat tgccaacaga acaaaatctc aaacttatgg ctagtgatga  14640

cagcagtcag ttgtcccatc tgtgacccac caaggctggc atgctggaat gagcaggctt  14700

tggtggcatg tagttactgg acagcaccac tgacatgggc aggggaaaaa ctgagcatgg  14760

tgtaaatcac tgcctcaaag ccacttctct gtgcctgcac catgcttgaa agctcttcta  14820

caggagctgg gtttgttcaa gaaagcttct gtttctccca tctgcttctt gtaccttcac  14880

agggacagag ttagaagggt acagccatgg ctggaagggg ctgactttca aatgtgccta  14940

attttccttt ggttgctgct gcagctgcag aagaaggggt tcagaagcca agagctttga  15000

gataaggatg cctaacctat gttgaagaca tttgtgctga cacctcaggc cccaggatag  15060

gacaactgct ggattgtggc taacccacta gctacagaac ctaatttata ttaccagatt  15120

aggaagagca aaagaacatg tatttataac aggaggtctt ctgtgcttct ctactaaaag  15180

gtgctgtgaa ggagcccaca gtgcagcagt gtatgaggcc tgaaagaggc cgcagcacac  15240

gaagagccct ggtaggagca gcacacagag gggcaggagg gctgggggaa ctgccaccca  15300

tggggacctg tgtgaagcag tgcactcctg aggggtggac tgcgtgggaa aggaaaagaa  15360

agcaaacaga cctgtgatga actgtcacac agactgcaga gtgacagagg agggcacgag  15420

gcagtgcgcc cactgcaggg agtggcgctc cttcctcaca gcagcgctaa cagcttggca  15480

ccaatattca gtagtctgtg gtgatacttt ttccagtttc accacacagc atttcgcttg  15540

ttctacttgt tttagctttc cccctccaca agataacaca tactttgcca gtcagtccct  15600

aagaccttaa cttaacagtt agcaaacagg atcttgcaaa agaaggaaga taacatgaca  15660

ccaccttcac tggtgtataa atagttcaaa tactttcctt cactttcccg taaattagtt  15720

gattgcaggt caggagataa caggggaact tactgcaaga gagaaaatga tgtttaatat  15780

tgtcttggac tttctggtgg tctgggcatg aaaatggggt actcaaaatc ctcgggacgt  15840

ttatttttca cctgatttat tcccaaactg cactatttct aggccattgg agttcttatc  15900

aattaaatta tactttggct ctctgctatc tcactccctt tcatcttcag catcactttc  15960

agcacaatta caggagaaga cttagactca gagctttagg actcatcata agaggctttc  16020

attgctctgt caccacaccc catatagatc t                                 16051


<210>  23
<211>  7334
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  pBS-OM-4.4 Vector

<400>  23
atcaagctta tcgataccgt cgacctcgag ggggggcccg gtacccagct tttgttccct     60

ttagtgaggg ttaatttcga gcttggcgta atcatggtca tagctgtttc ctgtgtgaaa    120

ttgttatccg ctcacaattc cacacaacat acgagccgga agcataaagt gtaaagcctg    180

gggtgcctaa tgagtgagct aactcacatt aattgcgttg cgctcactgc ccgctttcca    240

gtcgggaaac ctgtcgtgcc agctgcatta atgaatcggc caacgcgcgg ggagaggcgg    300

tttgcgtatt gggcgctctt ccgcttcctc gctcactgac tcgctgcgct cggtcgttcg    360

gctgcggcga gcggtatcag ctcactcaaa ggcggtaata cggttatcca cagaatcagg    420

ggataacgca ggaaagaaca tgtgagcaaa aggccagcaa aaggccagga accgtaaaaa    480

ggccgcgttg ctggcgtttt tccataggct ccgcccccct gacgagcatc acaaaaatcg    540

acgctcaagt cagaggtggc gaaacccgac aggactataa agataccagg cgtttccccc    600

tggaagctcc ctcgtgcgct ctcctgttcc gaccctgccg cttaccggat acctgtccgc    660

ctttctccct tcgggaagcg tggcgctttc tcatagctca cgctgtaggt atctcagttc    720

ggtgtaggtc gttcgctcca agctgggctg tgtgcacgaa ccccccgttc agcccgaccg    780

ctgcgcctta tccggtaact atcgtcttga gtccaacccg gtaagacacg acttatcgcc    840

actggcagca gccactggta acaggattag cagagcgagg tatgtaggcg gtgctacaga    900

gttcttgaag tggtggccta actacggcta cactagaagg acagtatttg gtatctgcgc    960

tctgctgaag ccagttacct tcggaaaaag agttggtagc tcttgatccg gcaaacaaac   1020

caccgctggt agcggtggtt tttttgtttg caagcagcag attacgcgca gaaaaaaagg   1080

atctcaagaa gatcctttga tcttttctac ggggtctgac gctcagtgga acgaaaactc   1140

acgttaaggg attttggtca tgagattatc aaaaaggatc ttcacctaga tccttttaaa   1200

ttaaaaatga agttttaaat caatctaaag tatatatgag taaacttggt ctgacagtta   1260

ccaatgctta atcagtgagg cacctatctc agcgatctgt ctatttcgtt catccatagt   1320

tgcctgactc cccgtcgtgt agataactac gatacgggag ggcttaccat ctggccccag   1380

tgctgcaatg ataccgcgag acccacgctc accggctcca gatttatcag caataaacca   1440

gccagccgga agggccgagc gcagaagtgg tcctgcaact ttatccgcct ccatccagtc   1500

tattaattgt tgccgggaag ctagagtaag tagttcgcca gttaatagtt tgcgcaacgt   1560

tgttgccatt gctacaggca tcgtggtgtc acgctcgtcg tttggtatgg cttcattcag   1620

ctccggttcc caacgatcaa ggcgagttac atgatccccc atgttgtgca aaaaagcggt   1680

tagctccttc ggtcctccga tcgttgtcag aagtaagttg gccgcagtgt tatcactcat   1740

ggttatggca gcactgcata attctcttac tgtcatgcca tccgtaagat gcttttctgt   1800

gactggtgag tactcaacca agtcattctg agaatagtgt atgcggcgac cgagttgctc   1860

ttgcccggcg tcaatacggg ataataccgc gccacatagc agaactttaa aagtgctcat   1920

cattggaaaa cgttcttcgg ggcgaaaact ctcaaggatc ttaccgctgt tgagatccag   1980

ttcgatgtaa cccactcgtg cacccaactg atcttcagca tcttttactt tcaccagcgt   2040

ttctgggtga gcaaaaacag gaaggcaaaa tgccgcaaaa aagggaataa gggcgacacg   2100

gaaatgttga atactcatac tcttcctttt tcaatattat tgaagcattt atcagggtta   2160

ttgtctcatg agcggataca tatttgaatg tatttagaaa aataaacaaa taggggttcc   2220

gcgcacattt ccccgaaaag tgccacctaa attgtaagcg ttaatatttt gttaaaattc   2280

gcgttaaatt tttgttaaat cagctcattt tttaaccaat aggccgaaat cggcaaaatc   2340

ccttataaat caaaagaata gaccgagata gggttgagtg ttgttccagt ttggaacaag   2400

agtccactat taaagaacgt ggactccaac gtcaaagggc gaaaaaccgt ctatcagggc   2460

gatggcccac tacgtgaacc atcaccctaa tcaagttttt tggggtcgag gtgccgtaaa   2520

gcactaaatc ggaaccctaa agggagcccc cgatttagag cttgacgggg aaagccggcg   2580

aacgtggcga gaaaggaagg gaagaaagcg aaaggagcgg gcgctagggc gctggcaagt   2640

gtagcggtca cgctgcgcgt aaccaccaca cccgccgcgc ttaatgcgcc gctacagggc   2700

gcgtcccatt cgccattcag gctgcgcaac tgttgggaag ggcgatcggt gcgggcctct   2760

tcgctattac gccagctggc gaaaggggga tgtgctgcaa ggcgattaag ttgggtaacg   2820

ccagggtttt cccagtcacg acgttgtaaa acgacggcca gtgaattgta atacgactca   2880

ctatagggcg aattggagct ccaccgcggt ggcggccgct ctagaactag tggatccttc   2940

ttaaaaagca gaccatcatt cactgcaaac ccagagcttc atgcctctcc ttccacaacc   3000

gaaaacagcc ggcttcattt gtctttttta aatgctgttt tccaggtgaa ttttggccag   3060

cgtgttggct gagatccagg agcacgtgtc agctttctgc tctcattgct cctgttctgc   3120

attgcctctt tctggggttt ccaagagggg gggagacttt gcgcggggat gagataatgc   3180

cccttttctt agggtggctg ctgggcagca gagtggctct gggtcactgt ggcaccaatg   3240

ggaggcacca gtgggggtgt gttttgtgca ggggggaagc attcacagaa tggggctgat   3300

cctgaagctt gcagtccaag gctttgtctg tgtacccagt gaaatccttc ctctgttaca   3360

taaagcccag ataggactca gaaatgtagt cattccagcc cccctcttcc tcagatctgg   3420

agcagcactt gtttgcagcc agtcctcccc aaaatgcaca gacctcgccg agtggaggga   3480

gatgtaaaca gcgaaggtta attacctcct tgtcaaaaac actttgtggt ccatagatgt   3540

ttctgtcaat cttacaaaac agaaccgaga ggcagcgagc actgaagagc gtgttcccat   3600

gctgagttaa tgagacttgg cagctcgctg tgcagagatg atccctgtgc ttcatgggag   3660

gctgtaacct gtctccccat cgccttcaca ccgcagtgct gtcctggaca cctcaccctc   3720

cataagctgt aggatgcagc tgcccaggga tcaagagact tttcctaagg ctcttaggac   3780

tcatctttgc cgctcagtag cgtgcagcaa ttactcatcc caactatact gaatgggttt   3840

ctgccagctc tgcttgtttg tcaataagca tttcttcatt ttgcctctaa gtttctctca   3900

gcagcaccgc tctgggtgac ctgagtggcc acctggaacc cgaggggcac agccaccacc   3960

tccctgttgc tgctgctcca gggactcatg tgctgctgga tggggggaag catgaagttc   4020

ctcacccaga cacctgggtt gcaatggctg cagcgtgctc ttcttggtat gcagattgtt   4080

tccagccatt acttgtagaa atgtgctgtg gaagcccttt gtatctcttt ctgtggccct   4140

tcagcaaaag ctgtgggaaa gctctgaggc tgctttcttg ggtcgtggag gaattgtatg   4200

ttccttcttt aacaaaaatt atccttagga gagagcactg tgcaagcatt gtgcacataa   4260

aacaattcag gttgaaaggg ctctctggag gtttccagcc tgactactgc tcgaagcaag   4320

gccaggttca aagatggctc aggatgctgt gtgccttcct gattatctgt gccaccaatg   4380

gaggagattc acagccactc tgcttcccgt gccactcatg gagaggaata ttcccttata   4440

ttcagataga atgttatcct ttagctcagc cttccctata accccatgag ggagctgcag   4500

atccccatac tctccccttc tctggggtga aggccgtgtc ccccagcccc ccttcccacc   4560

ctgtgcccta agcagcccgc tggcctctgc tggatgtgtg cctatatgtc aatgcctgtc   4620

cttgcagtcc agcctgggac atttaattca tcaccagggt aatgtggaac tgtgtcatct   4680

tcccctgcag ggtacaaagt tctgcacggg gtcctttcgg ttcaggaaaa ccttcactgg   4740

tgctacctga atcaagctct atttaataag ttcataagca catggatgtg ttttcctaga   4800

gatacgtttt aatggtatca gtgattttta tttgctttgt tgcttacttc aaacagtgcc   4860

tttgggcagg aggtgaggga cgggtctgcc gttggctctg cagtgatttc tccaggcgtg   4920

tggctcaggt cagatagtgg tcactctgtg gccagaagaa ggacaaagat ggaaattgca   4980

gattgagtca cgttaagcag gcatcttgga gtgatttgag gcagtttcat gaaagagcta   5040

cgaccactta ttgttgtttt ccccttttac aacagaagtt ttcatcaaaa taacgtggca   5100

aagcccagga atgtttggga aaagtgtagt taaatgtttt gtaattcatt tgtcggagtg   5160

ctaccagcta agaaaaaagt cctacctttg gtatggtagt cctgcagaga atacaacatc   5220

aatattagtt tggaaaaaaa caccaccacc accagaaact gtaatggaaa atgtaaacca   5280

agaaattcct tgggtaagag agaaaggatg tcgtatactg gccaagtcct gcccagctgt   5340

cagcctgctg accctctgca gttcaggacc atgaaacgtg gcactgtaag acgtgtcccc   5400

tgcctttgct tgcccacaga tctctgccct tgtgctgact cctgcacaca agagcatttc   5460

cctgtagcca aacagcgatt agccataagc tgcacctgac tttgaggatt aagagtttgc   5520

aattaagtgg attgcagcag gagatcagtg gcagggttgc agatgaaatc cttttctagg   5580

ggtagctaag ggctgagcaa cctgtcctac agcacaagcc aaaccagcca agggttttcc   5640

tgtgctgttc acagaggcag ggccagctgg agctggagga ggttgtgctg ggacccttct   5700

ccctgtgctg agaatggagt gatttctggg tgctgttcct gtggcttgca ctgagcagct   5760

caagggagat cggtgctcct catgcagtgc caaaactcgt gtttgatgca gaaagatgga   5820

tgtgcacctc cctcctgcta atgcagccgt gagcttatga aggcaatgag ccctcagtgc   5880

agcaggagct gtagtgcact cctgtaggtg ctagggaaaa tctctggttc ccagggatgc   5940

attcataagg gcaatatatc ttgaggctgc gccaaatctt tctgaaatat tcatgcgtgt   6000

tcccttaatt tatagaaaca aacacagcag aataattatt ccaatgcctc ccctcgaagg   6060

aaacccatat ttccatgtag aaatgtaacc tatatacaca cagccatgct gcatccttca   6120

gaacgtgcca gtgctcatct cccatggcaa aatactacag gtattctcac tatgttggac   6180

ctgtgaaagg aaccatggta agaaacttcg gttaaaggta tggctgcaaa actactcata   6240

ccaaaacagc agagctccag acctcctctt aggaaagagc cacttggaga gggatggtgt   6300

gaaggctgga ggtgagagac agagcctgtc ccagttttcc tgtctctatt ttctgaaacg   6360

tttgcaggag gaaaggacaa ctgtactttc aggcatagct ggtgccctca cgtaaataag   6420

ttccccgaac ttctgtgtca tttgttctta agatgctttg gcagaacact ttgagtcaat   6480

tcgcttaact gtgactaggt ctgtaaataa gtgctccctg ctgataaggt tcaagtgaca   6540

tttttagtgg tatttgacag catttacctt gctttcaagt cttctaccaa gctcttctat   6600

acttaagcag tgaaaccgcc aagaaaccct tccttttatc aagctagtgc taaataccat   6660

taacttcata ggttagatac ggtgctgcca gcttcacctg gcagtggttg gtcagttctg   6720

ctggtgacaa agcctccctg gcctgtgctt ttacctagag gtgaatatcc aagaatgcag   6780

aactgcatgg aaagcagagc tgcaggcacg atggtgctga gccttagctg cttcctgctg   6840

ggagatgtgg atgcagagac gaatgaagga cctgtccctt actcccctca gcattctgtg   6900

ctatttaggg ttctaccaga gtccttaaga ggtttttttt ttttttggtc caaaagtctg   6960

tttgtttggt tttgaccact gagagcatgt gacacttgtc tcaagctatt aaccaagtgt   7020

ccagccaaaa tcaattgcct gggagacgca gaccattacc tggaggtcag gacctcaata   7080

aatattacca gcctcattgt gccgctgaca gattcagctg gctgctccgt gttccagtcc   7140

aacagttcgg acgccacgtt tgtatatatt tgcaggcagc ctcgggggga ccatctcagg   7200

agcagagcac cggcagccgc ctgcagagcc gggcagtacc tcaccatggc catggcaggt   7260

gtcttcgtgc tgttctcttt cgtgctttgt ggcttcctcc caggtgagta actcccagag   7320

tgctgcagaa gctt                                                     7334


<210>  24
<211>  4327
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  pAVIJCR-A137.91.1.2 Vector

<400>  24
gccaatgtgg tacttcccac attgtataag aaatttggca agtttagagc aatgtttgaa     60

gtgttgggaa atttctgtat actcaagagg gcgtttttga caactgtaga acagaggaat    120

caaaaggggg tgggaggaag ttaaaagaag aggcaggtgc aagagagctt gcagtcccgc    180

tgtgtgtacg acactggcac catggctttg acctttgcct tactggtggc tctcctggtg    240

ctgagctgca agagcagctg ctctgtgggc tgcgatctgc ctcagaccca cagcctgggc    300

agcaggagga ccctgatgct gctggctcag atgaggagaa tcagcctgtt tagctgcctg    360

aaggataggc acgattttgg ctttcctcaa gaggagtttg gcaaccagtt tcagaaggct    420

gagaccatcc ctgtgctgca cgagatgatc cagcagatct ttaacctgtt tagcaccaag    480

gatagcagcg ctgcttggga tgagaccctg ctggataagt tttacaccga gctgtaccag    540

cagctgaacg atctggaggc ttgcgtgatc cagggcgtgg gcgtgaccga gacccctctg    600

atgaaggagg atagcatcct ggctgtgagg aagtactttc agaggatcac cctgtacctg    660

aaggagaaga agtacagccc ctgcgcttgg gaagtcgtga gggctgagat catgaggagc    720

tttagcctga gcaccaacct gcaagagagc ttgaggtcta aggagtaaaa agtctagagt    780

cggggcggcc ggccgcttcg agcagacatg ataagataca ttgatgagtt tggacaaacc    840

acaactagaa tgcagtgaaa aaaatgcttt atttgtgaaa tttgtgatgc tattgcttta    900

tttgtaacca ttataagctg caataaacaa gttaacaaca acaattgcat tcattttatg    960

tttcaggttc agggggaggt gtgggaggtt ttttaaagca agtaaaacct ctacaaatgt   1020

ggtaaaatcg ataaggatcc gtcgaccgat gcccttgaga gccttcaacc cagtcagctc   1080

cttccggtgg gcgcggggca tgactatcgt cgccgcactt atgactgtct tctttatcat   1140

gcaactcgta ggacaggtgc cggcagcgct cttccgcttc ctcgctcact gactcgctgc   1200

gctcggtcgt tcggctgcgg cgagcggtat cagctcactc aaaggcggta atacggttat   1260

ccacagaatc aggggataac gcaggaaaga acatgtgagc aaaaggccag caaaaggcca   1320

ggaaccgtaa aaaggccgcg ttgctggcgt ttttccatag gctccgcccc cctgacgagc   1380

atcacaaaaa tcgacgctca agtcagaggt ggcgaaaccc gacaggacta taaagatacc   1440

aggcgtttcc ccctggaagc tccctcgtgc gctctcctgt tccgaccctg ccgcttaccg   1500

gatacctgtc cgcctttctc ccttcgggaa gcgtggcgct ttctcaatgc tcacgctgta   1560

ggtatctcag ttcggtgtag gtcgttcgct ccaagctggg ctgtgtgcac gaaccccccg   1620

ttcagcccga ccgctgcgcc ttatccggta actatcgtct tgagtccaac ccggtaagac   1680

acgacttatc gccactggca gcagccactg gtaacaggat tagcagagcg aggtatgtag   1740

gcggtgctac agagttcttg aagtggtggc ctaactacgg ctacactaga aggacagtat   1800

ttggtatctg cgctctgctg aagccagtta ccttcggaaa aagagttggt agctcttgat   1860

ccggcaaaca aaccaccgct ggtagcggtg gtttttttgt ttgcaagcag cagattacgc   1920

gcagaaaaaa aggatctcaa gaagatcctt tgatcttttc tacggggtct gacgctcagt   1980

ggaacgaaaa ctcacgttaa gggattttgg tcatgagatt atcaaaaagg atcttcacct   2040

agatcctttt aaattaaaaa tgaagtttta aatcaatcta aagtatatat gagtaaactt   2100

ggtctgacag ttaccaatgc ttaatcagtg aggcacctat ctcagcgatc tgtctatttc   2160

gttcatccat agttgcctga ctccccgtcg tgtagataac tacgatacgg gagggcttac   2220

catctggccc cagtgctgca atgataccgc gagacccacg ctcaccggct ccagatttat   2280

cagcaataaa ccagccagcc ggaagggccg agcgcagaag tggtcctgca actttatccg   2340

cctccatcca gtctattaat tgttgccggg aagctagagt aagtagttcg ccagttaata   2400

gtttgcgcaa cgttgttgcc attgctacag gcatcgtggt gtcacgctcg tcgtttggta   2460

tggcttcatt cagctccggt tcccaacgat caaggcgagt tacatgatcc cccatgttgt   2520

gcaaaaaagc ggttagctcc ttcggtcctc cgatcgttgt cagaagtaag ttggccgcag   2580

tgttatcact catggttatg gcagcactgc ataattctct tactgtcatg ccatccgtaa   2640

gatgcttttc tgtgactggt gagtactcaa ccaagtcatt ctgagaatag tgtatgcggc   2700

gaccgagttg ctcttgcccg gcgtcaatac gggataatac cgcgccacat agcagaactt   2760

taaaagtgct catcattgga aaacgttctt cggggcgaaa actctcaagg atcttaccgc   2820

tgttgagatc cagttcgatg taacccactc gtgcacccaa ctgatcttca gcatctttta   2880

ctttcaccag cgtttctggg tgagcaaaaa caggaaggca aaatgccgca aaaaagggaa   2940

taagggcgac acggaaatgt tgaatactca tactcttcct ttttcaatat tattgaagca   3000

tttatcaggg ttattgtctc atgagcggat acatatttga atgtatttag aaaaataaac   3060

aaataggggt tccgcgcaca tttccccgaa aagtgccacc tgacgcgccc tgtagcggcg   3120

cattaagcgc ggcgggtgtg gtggttacgc gcagcgtgac cgctacactt gccagcgccc   3180

tagcgcccgc tcctttcgct ttcttccctt cctttctcgc cacgttcgcc ggctttcccc   3240

gtcaagctct aaatcggggg ctccctttag ggttccgatt tagtgcttta cggcacctcg   3300

accccaaaaa acttgattag ggtgatggtt cacgtagtgg gccatcgccc tgatagacgg   3360

tttttcgccc tttgacgttg gagtccacgt tctttaatag tggactcttg ttccaaactg   3420

gaacaacact caaccctatc tcggtctatt cttttgattt ataagggatt ttgccgattt   3480

cggcctattg gttaaaaaat gagctgattt aacaaaaatt taacgcgaat tttaacaaaa   3540

tattaacgtt tacaatttcc cattcgccat tcaggctgcg caactgttgg gaagggcgat   3600

cggtgcgggc ctcttcgcta ttacgccagc ccaagctacc atgataagta agtaatatta   3660

aggtacggga ggtacttgga gcggccgcaa taaaatatct ttattttcat tacatctgtg   3720

tgttggtttt ttgtgtgaat cgatagtact aacatacgct ctccatcaaa acaaaacgaa   3780

acaaaacaaa ctagcaaaat aggctgtccc cagtgcaagt gcaggtgcca gaacatttct   3840

ctatcgatag gtaccgagct cttacgcgtg ctagccccga tgtacgggcc agatatacgc   3900

gttgacattg attattgact agttattaat agtaatcaat tacggggtca ttagttcata   3960

gcccatatat ggagttccgc gttacataac ttacggtaaa tggcccgcct ggctgaccgc   4020

ccaacgaccc ccgcccattg acgtcaataa tgacgtatgt tcccatagta acgccaatag   4080

ggactttcca ttgacgtcaa tgggtggact atttacggta aactgcccac ttggcagtac   4140

atcaagtgta tcatatgcca agtacgcccc ctattgacgt caatgacggt aaatggcccg   4200

cctggcatta tgcccagtac atgaccttat gggactttcc tacttggcag tacatctacg   4260

tattagtcat cgctattacc atgcatggct ttgacctttg ccttactggt ggctctcctg   4320

gtgctta                                                             4327


<210>  25
<211>  244
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  The RRE (rev responsive element) sequence

<400>  25
aattgaggag ctttgttcct tgggttcttg ggagcagcag gaagcactat gggcgcagcg     60

tcaatgacgc tgacggtaca ggccagacaa ttattgtctg gtatagtgca gcagcagaac    120

aatttgctga gggctattga ggcgcaacag catctgttgc aactcacagt ctggggcatc    180

aagcagctcc aggcaagaat cctggctgtg gaaagatacc taaaggatca acagctcctg    240

gtac                                                                 244


<210>  26
<211>  158
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  The ALV CTE (constitutive transport element) sequence

<400>  26
aatgtgggga gggcaaggct tgcgaatcgg gttgtaacgg gcaaggcttg actgagggga     60

caatagcatg tttaggcgaa aagcggggct tcggttgtac gcggttagga gtcccctcag    120

gatatagtag tttcgctttt gcatagggag ggggaaat                            158


<210>  27
<211>  55
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  p10.0-OM-IFN-1 Primer

<400>  27
ggcgtcgacg gatccgttaa ccctagaact agtggatctc tgcccttgtg ctgac          55


<210>  28
<211>  31
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  p10.0-OM-IFN-2

<400>  28
ggcctcgagc ctagactttt tactccttag a                                    31


<210>  29
<211>  346
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  ALV vector 5' LTR sequence

<400>  29
aatgtagtct tatgcaatac tcttgtagtc ttgcaacatg cttatgtaac gatgagttag     60

caacatgcct tataaggaga gaaaaagcac cgtgcatgcc gattggtggg agtaaggtgg    120

tatgatcgtg gtatgatcgt gccttgttag gaaggcaaca gacgggtcta acacggattg    180

gacgaaccac tgaattccgc attgcagaga tattgtattt aagtgcctag ctcgatacaa    240

taaacgccat ttgaccattc accacattgg tgtgcacctg ggttgatggc cggaccgttg    300

attccctgrc gactacgagc acatgcatga agcagaaggc ttcatt                   346


